Health-Related Quality of Life or Quantity of Life: A Difficult Trade-Off in Primary Brain Tumors?

被引：23

作者：

Dirven, Linda ^{[1
]}

Reijneveld, Jaap C. ^{[1
,2
]}

Taphoorn, Martin J. B. ^{[1
,3
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

[3] Med Ctr Haaglanden, Dept Neurol, The Hague, Netherlands

来源：

SEMINARS IN ONCOLOGY | 2014年 / 41卷 / 04期

关键词：

PHASE-III TRIAL; NEWLY-DIAGNOSED GLIOBLASTOMA; LOW-GRADE GLIOMAS; RADIOTHERAPY PLUS CONCOMITANT; PROGRESSION-FREE SURVIVAL; RADIATION-THERAPY; ANAPLASTIC OLIGODENDROGLIOMA; EUROPEAN-ORGANIZATION; ADJUVANT TEMOZOLOMIDE; RANDOMIZED-TRIAL;

D O I：

10.1053/j.seminoncol.2014.06.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Health-related quality of life (HRQoL) measurements have become increasingly important in brain tumor research, next to traditional outcome measures such as overall and progression-free survival. Several validated questionnaires have been developed to measure HRQoL in clinical trials, as well as in clinical practice. In brain tumor patients, both the tumor and treatment may have an impact on HRQoL, which can be positive and negative. When determining the net clinical benefit of a new treatment strategy, both the quantity and quality of life (QOL) should be considered. Because treatment may benefit or harm both quantity and QOL, a trade-off discussion may arise when these two outcomes are conflicting. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：541 / 552

页数：12

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