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Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

被引：167
|
作者：
Chan, Wing-Kei
Ho, Chi-Ming
Wong, Man-Kin
Che, Chi-Ming
机构：
[1] Univ Hong Kong, Dept Chem, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 46期
关键词：
D O I：
10.1021/ja064479s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions. Copyright © 2006 American Chemical Society.
引用
收藏
页码：14796 / 14797
页数：2
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