Interaction of DNA-hydrolyzing autoantibodies from sera of patients with lymphoproliferative diseases with oligodeoxyribonucleotides in affinity trap assays

被引：0
|
作者：
Aleksandrova, ES
机构：
来源：
MOLECULAR BIOLOGY | 1996年 / 30卷 / 04期
关键词：
DNA-hydrolyzing autoantibodies; DNA-binding autoantibodies; DNA-protein interactions; lymphoproliferative diseases;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Improved techniques were developed for isolating DNA-hydrolyzing and DNA-binding autoantibodies from sera of patients with lymphoproliferative diseases, as well as a quantitative assay for the DNA-binding capacity, based on specific trapping of protein-oligodeoxyribonucleotide complexes on protein-A-Sepharose beads. The antibody-oligodeoxyribonucleotide binding constant thus determined was (1.8 +/- 0.2). 10(-10) M.
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页码：547 / 549
页数：3
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