Selective formation of pyrrola[3,2-d]pyrimidines from methyl[(N-benzoyl-S-methylisoihiocarbamoyl)amino]-1H-pyrrole-2-carboxylate

被引：9

作者：

Pathak, VP ^{[1
]}

机构：

[1] BioCryst Pharmaceut Inc, Birmingham, AL 35244 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2000年 / 4卷 / 02期

关键词：

D O I：

10.1021/op9901902

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A selective conversion of methyl 3-{[(benzoylamino)(methylsulfanyl)methylidene]amino}-4-(3-pyridinylmethyl)-1H-pyrrole-2-carboxylate (1a) to 2-amino-7-(3-pyridinylmethyl)-3,5-dihydro-4H-pyrrolo [3,2-d]pyrimidine-4-one (2a) in methanolic ammonia in the presence of sodium amide is described.

引用

页码：129 / 130

页数：2

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