Selective formation of pyrrola[3,2-d]pyrimidines from methyl[(N-benzoyl-S-methylisoihiocarbamoyl)amino]-1H-pyrrole-2-carboxylate

被引：9
|
作者：
Pathak, VP [1 ]
机构：
[1] BioCryst Pharmaceut Inc, Birmingham, AL 35244 USA
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2000年 / 4卷 / 02期
关键词：
D O I：
10.1021/op9901902
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A selective conversion of methyl 3-{[(benzoylamino)(methylsulfanyl)methylidene]amino}-4-(3-pyridinylmethyl)-1H-pyrrole-2-carboxylate (1a) to 2-amino-7-(3-pyridinylmethyl)-3,5-dihydro-4H-pyrrolo [3,2-d]pyrimidine-4-one (2a) in methanolic ammonia in the presence of sodium amide is described.
引用
收藏
页码：129 / 130
页数：2
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