Stereoselective Methodology for the Synthesis of an Antifungal Allylamine: Terbinafine

被引：2

作者：

Gupta, Bhavna ^{[1
]}

Babu, B. Ravindra ^{[1
]}

Gyanda, Kapil ^{[1
]}

Panda, Siva S. ^{[1
]}

Jain, Subhash C. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2014年 / 11卷 / 02期

关键词：

Terbinafine; alkylation; stereoselective synthesis; selective reduction; antifungal drug; DERIVATIVES; EFFICIENT; NAFTIFINE; VINYL;

D O I：

10.2174/15701786113106660078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of an antifungal drug, Terbinafine, bearing (E)-tert-butylenyne structural element as the side chain is achieved by coupling N-methyl-1-napthalene methanamine with 1-bromo-6,6-dimethyl-2E-hepten-4-yne in good yield. The new methodology avoids the use of toxic starting materials like acrolein and phosphorous pentachloride that were used in earlier reports. The structure was confirmed by IR, NMR, MS, and elemental analysis.

引用

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页码：141 / 144

页数：4

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