Preferential spinal cord volume loss in primary progressive multiple sclerosis

被引：44

作者：

Tsagkas, Charidimos ^{[1
,2
]}

Magon, Stefano ^{[1
,2
]}

Gaetano, Laura ^{[1
,2
]}

Pezold, Simon ^{[3
]}

Naegelin, Yvonne ^{[1
]}

Amann, Michael ^{[1
,2
,4
]}

Stippich, Christoph ^{[4
]}

Cattin, Philippe ^{[3
]}

Wuerfel, Jens ^{[2
,3
]}

Bieri, Oliver ^{[5
]}

Sprenger, Till ^{[1
,6
]}

Kappos, Ludwig ^{[1
]}

Parmar, Katrin ^{[1
]}

机构：

[1] Univ Basel, Univ Hosp Basel, Dept Neurol, Petersgraben 4, CH-4031 Basel, Switzerland

[2] MIAC AG, Basel, Switzerland

[3] Univ Basel, Dept Biomed Engn, Basel, Switzerland

[4] Univ Basel, Univ Hosp Basel, Dept Radiol, Div Diagnost & Intervent Neuroradiol, Basel, Switzerland

[5] Univ Basel, Div Radiol Phys, Dept Radiol, Univ Hosp Basel, Basel, Switzerland

[6] DKD HELIOS Klin Wiesbaden, Dept Neurol, Wiesbaden, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2019年 / 25卷 / 07期

关键词：

Multiple sclerosis; MRI; atrophy; biomarkers; DEEP GRAY-MATTER; CERVICAL CORD; ATROPHY; BRAIN; MRI; MS; DISABILITY; ASSOCIATION;

D O I：

10.1177/1352458518775006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS). Objective: Longitudinal evaluation of SCV loss in PPMS and its correlation to clinical outcomes, compared to relapse-onset multiple sclerosis (MS) subtypes. Methods: A total of 60 MS age-, sex- and disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) and secondary progressive MS (SPMS)) were analysed annually over 6 years of follow-up. The upper cervical SCV was measured on 3D T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) images using a semi-automatic software (CORDIAL), along with the total brain volume (TBV), brain T2 lesion volume (T2LV) and Expanded Disability Status Scale (EDSS). Results: PPMS showed faster SCV loss over time than RRMS (p < 0.01) and by trend (p = 0.066) compared with SPMS. In contrast to relapse-onset MS, in PPMS SCV loss progressed independent of TBV and T2LV changes. Moreover, in PPMS, SCV was the only magnetic resonance imaging (MRI) measurement associated with EDSS increase over time (p < 0.01), as opposed to RRMS and SPMS. Conclusion: SCV loss is a strong predictor of clinical outcomes in PPMS and has shown to be faster and independent of brain MRI metrics compared to relapse-onset MS.

引用

页码：947 / 957

页数：11

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