DUAL TARGETING OF MDMX AND MDM2 HAS ANTILEUKEMIC ACTIVITY

被引：0
|
作者：
不详
机构：
来源：
CANCER DISCOVERY | 2018年 / 8卷 / 06期
关键词：
D O I：
10.1158/2159-8290.CD-RW2018-068
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：674 / 674
页数：1
相关论文
共 50 条
  • [41] Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers
    Dolezelova, Pavlina
    Cetkovska, Katerina
    Vousden, Karen H.
    Uldrijan, Stjepan
    [J]. CELL CYCLE, 2012, 11 (05) : 953 - 962
  • [42] Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition
    Carotti, Andrea
    Macchiarulo, Antonio
    Giacche, Nicola
    Pellicciari, Roberto
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2009, 77 (03) : 524 - 535
  • [43] Src phosphorylated Mdm2 requires MdmX to act as a neddylating ligase
    Hauck, Paula M.
    Mayo, Lindsey D.
    [J]. CANCER RESEARCH, 2016, 76
  • [44] Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    Sharp, DA
    Kratowicz, SA
    Sank, MJ
    George, DL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (53) : 38189 - 38196
  • [45] An Efficient Protein System for Screening Specific MdmX and Mdm2 Inhibitors
    Chen, Rong
    Zhou, Jingjing
    Qin, Lingyun
    Su, Zhengding
    [J]. BIOPHYSICAL JOURNAL, 2017, 112 (03) : 495A - 495A
  • [46] DNA damage-induced MDMX degradation is mediated by MDM2
    Kawai, H
    Wiederschain, D
    Kitao, H
    Stuart, J
    Tsai, KKC
    Yuan, ZM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) : 45946 - 45953
  • [47] MDM2, MDMX and p53 in oncogenesis and cancer therapy
    Wade, Mark
    Li, Yao-Cheng
    Wahl, Geoffrey M.
    [J]. NATURE REVIEWS CANCER, 2013, 13 (02) : 83 - 96
  • [48] MDM2 and MDMX: alone and together in regulation of p53
    Shadfan, Miriam
    Lopez-Pajares, Vanessa
    Yuan, Zhi-Min
    [J]. TRANSLATIONAL CANCER RESEARCH, 2012, 1 (02) : 88 - 99
  • [49] c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation
    Waning, David L.
    Lehman, Jason A.
    Batuello, Christopher N.
    Mayo, Lindsey D.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (01) : 216 - 222
  • [50] Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer
    Jing Xiong
    Jiansha Li
    Qin Yang
    Jun Wang
    Tiefen Su
    Sheng Zhou
    [J]. Breast Cancer Research, 19
12345