Bacteroides Induce Higher IgA Production Than Lactobacillus by Increasing Activation-Induced Cytidine Deaminase Expression in B Cells in Murine Peyer's Patches

被引：44

作者：

Yanagibashi, Tsutomu ^{[1
]}

Hosono, Akira ^{[1
]}

Oyama, Akihito ^{[1
]}

Tsuda, Masato ^{[1
]}

Hachimura, Satoshi ^{[2
]}

Takahashi, Yoshimasa ^{[3
]}

Itoh, Kikuji ^{[4
]}

Hirayama, Kazuhiro ^{[4
]}

Takahashi, Kyoko ^{[1
]}

Kaminogawa, Shuichi ^{[1
]}

机构：

[1] Nihon Univ, Dept Food Sci & Technol, Fujisawa, Kanagawa 2528510, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Res Ctr Food Safety, Bunkyo Ku, Tokyo 1138657, Japan

[3] Natl Inst Infect Dis, Dept Immunol, Shinjuku Ku, Tokyo 1628640, Japan

[4] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Publ Hlth, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 02期

关键词：

IgA; intestinal commensal bacteria; Bacteroides; Peyer's patches; activation-induced cytidine deaminase; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL DENDRITIC CELLS; CLASS SWITCH RECOMBINATION; MUCOSAL IMMUNE-SYSTEM; LACTIC-ACID BACTERIA; GERMINAL-CENTERS; LAMINA PROPRIA; GUT; RESPONSES; FRUCTOOLIGOSACCHARIDES;

D O I：

10.1271/bbb.80612

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gut mucosal immune system is crucial in host defense against infection by pathogenic microbacteria and viruses via the production of IgA. Previous studies have shown that intestinal commensal bacteria enhance mucosal IgA production. However, it is poorly understood how these bacteria induce IgA production and which genera of intestinal commensal bacteria induce IgA production effectively. In this study, we compared the immunomodulatory effects of Bacteroides and Lactobacillus on IgA production by Peyer's patches lymphocytes. IgA production by Peyer's patches lymphocytes co-cultured with Bacteroides was higher than with Lactobacillus. In addition, the expression of activation-induced. cytidine deaminase increased in co-culture with Bacteroides but not with Lactobacillus. We found that intestinal commensal bacteria elicited IgA production. In particular, Bacteroides induced the differentiation of Peyer's patches B cell into IgA(+) B cells by increasing activation-induced cytidine deaminase expression.

引用

页码：372 / 377

页数：6

共 27 条

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JOURNAL OF IMMUNOLOGY, 2007, 179 (07): : 4929 - 4938
[22] Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease
Nagata, Keiko
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VIRAL IMMUNOLOGY, 2017, 30 (03) : 240 - 249
[23] HIV induces the expression of activation-induced cytidine deaminase (AICDA) in B cells through a direct interaction between virion-associated CD40L and CD40
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Infectious Agents and Cancer, 4 (Suppl 2)
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[25] Complexes between nuclear factor-κB p65 and signal transducer and activator of transcription 3 are key actors in inducing activation-induced cytidine deaminase expression and immunoglobulin A production in CD40L plus interleukin-10-treated human blood B cells
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[26] Comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome"
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Nicoletti, Antonino
JOURNAL OF IMMUNOLOGY, 2008, 180 (04):
[27] Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome"
Bombardieri, Michele
Barone, Francesca
Pitzalis, Costantino
JOURNAL OF IMMUNOLOGY, 2008, 180 (04): : 2008 - 2009

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