Bacteroides Induce Higher IgA Production Than Lactobacillus by Increasing Activation-Induced Cytidine Deaminase Expression in B Cells in Murine Peyer's Patches

被引：44

作者：

Yanagibashi, Tsutomu ^{[1
]}

Hosono, Akira ^{[1
]}

Oyama, Akihito ^{[1
]}

Tsuda, Masato ^{[1
]}

Hachimura, Satoshi ^{[2
]}

Takahashi, Yoshimasa ^{[3
]}

Itoh, Kikuji ^{[4
]}

Hirayama, Kazuhiro ^{[4
]}

Takahashi, Kyoko ^{[1
]}

Kaminogawa, Shuichi ^{[1
]}

机构：

[1] Nihon Univ, Dept Food Sci & Technol, Fujisawa, Kanagawa 2528510, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Res Ctr Food Safety, Bunkyo Ku, Tokyo 1138657, Japan

[3] Natl Inst Infect Dis, Dept Immunol, Shinjuku Ku, Tokyo 1628640, Japan

[4] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Publ Hlth, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 02期

关键词：

IgA; intestinal commensal bacteria; Bacteroides; Peyer's patches; activation-induced cytidine deaminase; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL DENDRITIC CELLS; CLASS SWITCH RECOMBINATION; MUCOSAL IMMUNE-SYSTEM; LACTIC-ACID BACTERIA; GERMINAL-CENTERS; LAMINA PROPRIA; GUT; RESPONSES; FRUCTOOLIGOSACCHARIDES;

D O I：

10.1271/bbb.80612

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gut mucosal immune system is crucial in host defense against infection by pathogenic microbacteria and viruses via the production of IgA. Previous studies have shown that intestinal commensal bacteria enhance mucosal IgA production. However, it is poorly understood how these bacteria induce IgA production and which genera of intestinal commensal bacteria induce IgA production effectively. In this study, we compared the immunomodulatory effects of Bacteroides and Lactobacillus on IgA production by Peyer's patches lymphocytes. IgA production by Peyer's patches lymphocytes co-cultured with Bacteroides was higher than with Lactobacillus. In addition, the expression of activation-induced. cytidine deaminase increased in co-culture with Bacteroides but not with Lactobacillus. We found that intestinal commensal bacteria elicited IgA production. In particular, Bacteroides induced the differentiation of Peyer's patches B cell into IgA(+) B cells by increasing activation-induced cytidine deaminase expression.

引用

页码：372 / 377

页数：6

共 27 条

[1] Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies
Hsu, Hui-Chen
Wu, Yalei
Yang, PingAr
Wu, Qi
Job, Godwin
Chen, Jian
Wang, John
Accavitti-Loper, Mary Ann V.
Grizzle, William E.
Carter, Rohert H.
Mountz, John D.
JOURNAL OF IMMUNOLOGY, 2007, 178 (08): : 5357 - 5365
[2] Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase
Willenbrock, K
Jungnickel, B
Hansmann, ML
Küppers, R
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (10) : 3002 - 3007
[3] The Herbicide Isoproturon Induces Activation-Induced Cytidine Deaminase Expression in Germinal Center B Cells
Leeman-Neill, Rebecca J.
Johnson, Daniel E.
Swerdlow, Steven H.
BLOOD, 2015, 126 (23)
[4] Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity
Lombard-Vadnais, Felix
Chabot-Roy, Genevieve
Zahn, Astrid
Torres, Sahily Rodriguez
Noia, Javier M. Di
Melichar, Heather J.
Lesage, Sylvie
ISCIENCE, 2023, 26 (01)
[5] Enhanced expression of activation-induced cytidine deaminase in memory B cells provokes skewed immunoglobulin profile in advanced cirrhosis
Doi, Hiroyoshi
Kaplan, David E.
Morikawa, Kenichi
Eguchi, Junichi
Ito, Takayoshi
Kanto, Tatsuya
Yoshida, Hitoshi
HEPATOLOGY, 2016, 64 : 363A - 363A
[6] Differentisoforms of BSAP protein regulate the expression of activation-induced cytidine deaminase (AID) in normal and CLL B-cells.
Oppezzo, PJ
Dumas, GM
Lalanne, AI
Pritsch, OF
Vuillier, FM
Dighiero, GJ
BLOOD, 2004, 104 (11) : 526A - 526A
[7] Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
Muramatsu, M
Sankaranand, VS
Anant, S
Sugai, M
Kinoshita, K
Davidson, NO
Honjo, T
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) : 18470 - 18476
[8] T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells
Ueda, Yoshihiro
Liao, Dongmei
Yang, Kaiyong
Patel, Anjali
Kelsoe, Garnett
JOURNAL OF IMMUNOLOGY, 2007, 178 (06): : 3593 - 3601
[9] A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
Kotani, A
Okazaki, I
Muramatsu, M
Kinoshita, K
Begum, NA
Nakajima, T
Saito, H
Honjo, T
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (12) : 4506 - 4511
[10] Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone
Albesiano, E
Messmer, BT
Damle, RN
Allen, SL
Rai, KR
Chiorazzi, N
BLOOD, 2003, 102 (09) : 3333 - 3339

← 1 2 3 →