Utility of blood procalcitonin concentration in the management of cancer patients with infections

被引：34

作者：

Durnas, Bonita ^{[1
,2
]}

Watek, Marzena ^{[1
]}

Wollny, Tomasz ^{[1
]}

Niemirowicz, Katarzyna ^{[3
]}

Marzec, Michal ^{[4
]}

Bucki, Robert ^{[2
,3
]}

Gozdz, Stanislaw ^{[1
]}

机构：

[1] Holy Cross Oncol Ctr Kielce, Kielce, Poland

[2] Jan Kochanowski Univ Kielce, Dept Physiol Pathophysiol & Microbiol Infect, Fac Hlth Sci, Kielce, Poland

[3] Med Univ Bialystok, Dept Microbiol & Nanobiomed Engn, Mickiewicza 2c, PL-15222 Bialystok, Poland

[4] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

关键词：

procalcitonin; cancer; infection; C-REACTIVE PROTEIN; CRITICALLY-ILL PATIENTS; SERUM PROCALCITONIN; BACTERIAL-INFECTION; MARKER; BACTEREMIA; BIOMARKER; SEPSIS; PARAMETERS; CALCITONIN;

D O I：

10.2147/OTT.S95600

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT) is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physical examination and an appropriate microbiological assessment.

引用

页码：469 / 475

页数：7

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