Novel ferrocenyl ligands with planar and central chirality in Pd-catalyzed allylic substitutions

被引：58
|
作者：
Enders, D [1 ]
Peters, R [1 ]
Runsink, J [1 ]
Bats, JW [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
ORGANIC LETTERS | 1999年 / 1卷 / 11期
关键词：
D O I：
10.1021/ol991139l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The use of planar chiral ferrocenyl ligands bearing a stereogenic center in beta-position of the side chain was investigated in Pd-catalyzed enantioselective allylic substitutions. By employing 2.2 mol % of a P,S-ligand and 1.0 mol % of [Pd(eta(3)-C3H5)Cl](2), the alkylation of the standard test system (+/-) (E)-diphenyl-2-propenyl acetate using dimethylmalonate/BSA as nucleophile proceeded in quantitative yield with an ee of 97%, which is the best value reported so far in this reaction using a P,S-ligand.
引用
收藏
页码：1863 / 1866
页数：4
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