Liver Function, In-Hospital, and Post-Discharge Clinical Outcome in Patients With Acute Heart Failure-Results From the Relaxin for the Treatment of Patients With Acute Heart Failure Study

被引:40
|
作者
van Deursen, Vincent M. [1 ]
Edwards, Christopher [2 ]
Cotter, Gad [2 ]
Davison, Beth A. [2 ]
Damman, Kevin [1 ]
Teerlink, John R. [3 ]
Metra, Marco [4 ]
Felker, G. Michael [5 ]
Ponikowski, Piotr [6 ]
Unemori, Elaine [7 ]
Severin, Thomas [8 ]
Voors, Adriaan A. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
[2] Momentum Res, Durham, NC USA
[3] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Cardiol Sect, San Francisco, CA 94143 USA
[4] Univ Brescia, Dept Expt & Appl Sci, Sect Cardiovasc Dis, Brescia, Italy
[5] Duke Univ, Duke Clin Res Inst, Durham, NC USA
[6] Med Univ, Dept Hlth Sci, Mil Hosp, Dept Cardiol, Wroclaw, Poland
[7] Corthera, San Mateo, CA USA
[8] Novartis Pharmaceut, Basel, Switzerland
关键词
Liver function; acute decompensated heart failure; prognosis; FUNCTION TESTS; FUNCTION ABNORMALITIES; MORTALITY; PROGRAM;
D O I
10.1016/j.cardfail.2014.03.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Elevated plasma concentrations of liver function tests are prevalent in patients with chronic heart failure (HF). Little is known about liver function in patients with acute HF. We aimed to assess the prevalence and prognostic value of serial measurements of liver function tests in patients admitted with acute decompensated HF. Methods: We investigated liver function tests from all 234 patients from the Relaxin for the Treatment of Patients With Acute Heart Failure study at baseline and during hospitalization. The end points were worsening HF through day 5, 60-day mortality or rehospitalization, and 180-day mortality. Results: Mean age was 70 +/- 10 years, 56% were male, and most patients were in New York Heart Association functional class III/IV (73%). Abnormal liver function tests were frequently found. for alanine transaminase (ALT; 12%), aspartate transaminase (AST; 21%), alkaline phosphatase (12%), and total bilirubin (19%), and serum albumin (25%) and total protein (9%) were decreased. In-hospital changes were very small. On a continuous scale, baseline ALT and AST were associated with 180-day mortality (hazard ratios [HRs; per doubling] 1.52 [P = .030] and 1.97 [P = .013], respectively) and worsening HF through day 5 (HRs [per doubling] 1.72 [P = .005] and 1.95 [P = .008], respectively). Albumin was associated with 180-day mortality (HR 0.86; P = .001) but not with worsening HF (HR 0.95; P = .248). Total protein was associated with only worsening HF (HR 0.91; P = .004). Conclusions: Abnormal liver function tests are often present in patients with acute HF and are associated with an increased risk for mortality, rehospitalization, and in-hospital worsening HF.
引用
收藏
页码:407 / 413
页数:7
相关论文
共 50 条
  • [31] Late In-Hospital Management of Patients Hospitalized with Acute Heart Failure
    Cyrille, Nicole B.
    Patel, Snehal R.
    PROGRESS IN CARDIOVASCULAR DISEASES, 2017, 60 (02) : 198 - 204
  • [32] A simple way of predicting post-discharge outcome in advanced heart failure patients
    Martins, H.
    Saraiva, F.
    Baptista, R.
    Jorge, E.
    Mendes, P. L.
    Monteiro, P.
    Costa, S.
    Franco, F.
    Providencia, L. A.
    EUROPEAN HEART JOURNAL SUPPLEMENTS, 2010, 12 (0F) : F118 - F118
  • [33] Influence of Cholesterol on In-hospital Outcomes in Patients with Acute Heart Failure
    Maruyama, Nlichiro
    Yamamura, Minako
    Hamaoka, Takuto
    Inoue, Oto
    Aburadani, Isao
    Hirazawa, Motoaki
    Nagata, Yoshiki
    Usuda, Kazuc
    JOURNAL OF CARDIAC FAILURE, 2012, 18 (10) : S149 - S149
  • [34] Prognostic impact of in-hospital hyperglycemia in hospitalized patients with acute heart failure: Results of the IN-HF (Italian Network on Heart Failure) Outcome registry
    Targher, Giovanni
    Dauriz, Marco
    Tavazzi, Luigi
    Temporelli, Pier Luigi
    Lucci, Donata
    Urso, Renato
    Lecchi, Gabriella
    Bellanti, Giancarlo
    Merlo, Marco
    Rossi, Andrea
    Maggioni, Aldo P.
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 203 : 587 - 593
  • [35] Influence of morphine treatment on in-hospital mortality among patients with acute heart failure
    Dominguez-Rodriguez, A.
    Avanzas, P.
    Burillo-Putze, G.
    Abreu-Gonzatez, R.
    MEDICINA INTENSIVA, 2017, 41 (06) : 382 - 384
  • [36] Nocturnal thoracic volume overload and post-discharge outcomes in patients hospitalized for acute heart failure
    Chang, Hao-Chih
    Huang, Chi-Jung
    Cheng, Hao-Min
    Yu, Wen-Chung
    Chiang, Chern-En
    Sung, Shih-Hsien
    Chen, Chen-Huan
    ESC HEART FAILURE, 2020, 7 (05): : 2807 - 2817
  • [37] Post-discharge medication reviews for patients with heart failure: a pilot study
    Anne Ponniah
    Sepehr Shakib
    Christopher J. Doecke
    Merelyn Boyce
    Manya Angley
    Pharmacy World & Science, 2008, 30
  • [38] Post-discharge medication reviews for patients with heart failure: a pilot study
    Ponniah, Anne
    Shakib, Sepehr
    Doecke, Christopher J.
    Boyce, Merelyn
    Angley, Manya
    PHARMACY WORLD & SCIENCE, 2008, 30 (06): : 810 - 815
  • [39] IN-HOSPITAL OUTCOMES OF PATIENTS WITH DEPRESSION AND ACUTE HEART FAILURE IN ACUTE SETTING.
    Kaur, Sukhpreet
    Ebner, Bertrand F.
    Dangl, Michael
    Hernandez, Rafael J.
    Albosta, Michael
    Grant, Jelani
    Vincent, Louis
    Colombo, Rosario
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 81 (08) : 754 - 754
  • [40] ACUTE HF score predicts in-hospital mortality in patients with acute heart failure
    Pastore, M. C.
    Mandoli, G. E.
    Campora, A.
    Renzelli, A.
    Olivoni, G.
    Toscano, M.
    Pavoncelli, S.
    Delcuratolo, E.
    Lambardi, M.
    Morrone, F.
    Cavigli, L.
    Focardi, M.
    D'ascenzi, F.
    Valente, S.
    Cameli, M.
    EUROPEAN HEART JOURNAL, 2023, 44