Two new phenazine metabolites with antimicrobial activities from soil-derived Streptomyces species

被引：21
|
作者：
Hu, Linfang [1 ]
Chen, Xiao [1 ]
Han, Li [2 ]
Zhao, Lixing [1 ]
Miao, Cuiping [1 ]
Huang, Xueshi [2 ]
Chen, Youwei [1 ]
Li, Ping [1 ]
Li, Yiqing [1 ]
机构：
[1] Yunnan Univ, Coll Life Sci, Minist Educ, Key Lab Microbial Divers Southwest China, Kunming 650091, Yunnan, Peoples R China
[2] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Liaoning, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 07期
基金：
中国国家自然科学基金;
关键词：
NATURAL-PRODUCTS;
D O I：
10.1038/s41429-019-0163-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two new phenazine metabolites, 6-hydroxyphenazine-1-carboxamide (1) and methyl 6-carbamoylphenazine-1-carboxylate (2), were isolated from a soil-derived Streptomyces diastaticus subsp. ardesiacus strain YIM PH20246, and their structures were elucidated by extensive spectroscopic data analysis. The antimicrobial activities of the isolates were assayed. Compound 1 showed moderate antifungal and antibacterial activities against Fusarium oxysporum (ATCC 7808), Fusarium solani (ATCC 36031) and Plectosphaerella cucumerina (local isolate), Staphylococcus aureus (ATCC 25923) and Staphylococcus albus (ATCC 10231), respectively. Compound 2 exhibited moderate antifungal and antibacterial activities against F. oxysporum, F. solani, and Phoma herbarum, S. aureus, S. albus, and Bacillus subtilis, respectively.
引用
收藏
页码：574 / 577
页数：4
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