First-in-class, first-in-human phase I trial of KPT-330, a selective inhibitor of nuclear export (SINE) in patients (pts) with advanced solid tumors.

被引:0
|
作者
Razak, Albiruni R. A.
Soerensen, Morten Mau
Mahipal, Amit
Shacham, Sharon
Yau, Cindy Y. F.
Lassen, Ulrik Niels
McCauley, Dilara
Cooksey, Jennifer
Tan, David Shao Peng
Saint-Martin, Jean-Richard
Landesman, Yossi
Pond, Gregory
Oza, Amit M.
Kauffman, Michael
Siu, Lillian L.
Mirza, Mansoor Raza
机构
[1] Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark
[3] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
[4] Karyopharm Therapeut, Newton, MA USA
[5] Ozmosis Res Inc, Toronto, ON, Canada
[6] Rigshosp, DK-2100 Copenhagen, Denmark
[7] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2505
引用
收藏
页数:1
相关论文
共 50 条
  • [41] A first-in-human phase I study of U3-1287 (AMG 888), a HER3 inhibitor, in patients (pts) with advanced solid tumors.
    Berlin, J.
    Keedy, V. L.
    Janne, P. A.
    Yee, L.
    Rizvi, N. A.
    Jin, X.
    Copigneaux, C.
    Hettmann, T.
    Beaupre, D. M.
    LoRusso, P.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [42] A phase 1 dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with heavily pretreated non-Hodgkin lymphoma (NHL).
    Gutierrez, Martin
    Goy, Andre
    Byrd, John C.
    Flynn, Joseph M.
    Sorensen, Morten
    Brown, Peter
    Gabrail, Nashat Y.
    Savona, Michael
    Flinn, Ian
    Baz, Rachid C.
    Shah, Bijal D.
    Stone, Richard M.
    Jacobsen, Eric
    Kukreti, Vishal
    Tiedemann, Roger E.
    Rashal, Tami
    Mirza, Mansoor Raza
    Shacham, Sharon
    Kauffman, Michael
    Kuruvilla, John
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [43] First-in-human phase 1/1b trial of the first-in-class bi-steric mTORC1-selective inhibitor RMC-5552 in patients with advanced solid tumors
    Schram, Alison M.
    Nagash, Abdul Rafeh
    Haura, Eric B.
    Riess, Jonathan W.
    Ulahannan, Susanna V.
    Ou, Sai-Hong I.
    Capasso, Anna
    Munster, Pamela N.
    Cheng, Michael L.
    Gustafson, W. Clay
    Bitman, Bojena
    Kar, Sumit
    Wang, Zhican
    Tao, Lin
    Meyerowitz, Justin G.
    Burns, Howard A.
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [44] Phase I, first-in-human trial of an oral VEGFR tyrosine kinase inhibitor (TKI) x-82 in patients (pts) with advanced solid tumors
    Moore, Kathleen N.
    Jones, Suzanne Fields
    Kurkjian, Carla
    Arkenau, Hendrik-Tobias
    Infante, Jeffrey R.
    Pant, Shubham
    Burris, Howard A.
    McMeekin, D. Scott
    Gibbons, Jay
    Harrow, Kimberly
    Liang, Chris
    Ramsey, Sara
    Bendell, Johanna C.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [45] First-in-human phase 1 trial (DRAGON) of SRK-181, a potential first-in-class selective latent TGFβ1 inhibitor, alone or in combination with anti-PD-(L)1 treatment in patients with advanced solid tumors.
    Yap, Timothy A.
    Barve, Minal A.
    Gainor, Justin F.
    Weekes, Colin D.
    Bockorny, Bruno
    Ju, Yawen
    Faucette, Ryan
    Bilic, Sanela
    Lee-Hoeflich, Si Tuen
    Song, Guochen
    Chyung, Yung
    Legler, Michelle
    Gan, Lu
    Bendell, Johanna C.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [46] A first-in-class, first-in-human phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with metastatic refractory solid tumors.
    Richards, J. M.
    Warso, M. A.
    Mehta, D.
    Christov, K.
    Schaeffer, C. M.
    Yamada, T.
    Beattie, C. W.
    Bressler, L. R.
    Das Gupta, T. K.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [47] Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors
    Rodon, Jordi
    Argiles, Guillem
    Connolly, Roisin M.
    Vaishampayan, Ulka
    de Jonge, Maja
    Garralda, Elena
    Giannakis, Marios
    Smith, David C.
    Dobson, Jason R.
    McLaughlin, Margaret
    Seroutou, Abdelkader
    Ji, Yan
    Dolan, Sinead
    Morawiak, Jennifer
    Moody, Susan
    Janku, Filip
    CANCER RESEARCH, 2018, 78 (13)
  • [48] Safety and antitumor activity of selinexor (KPT-330), a first-in -class, oral XPO1 selective inhibitor of nuclear export: A phase I study expanded with colon cancer cohort.
    Mau-Soerensen, Morten
    Razak, Albiruni R. A.
    Mahipal, Amit
    Mahaseth, Hemchandra
    Gerecitano, John F.
    Shacham, Sharon
    Yau, Cindy Y. F.
    Lassen, Ulrik
    Shields, Anthony Frank
    McCauley, Dilara
    Cooksey, Jennifer
    Tan, David Shao Peng
    Rashal, Tami
    Shacham, Eran
    Landesman, Yosef
    Pond, Gregory
    Oza, Amit M.
    Kauffman, Michael
    Siu, Lillian
    Mirza, Mansoor Raza
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (03)
  • [49] A phase I trial of GRN163L (GRN), a first-in-class telomerase inhibitor, in advanced solid tumors
    Ratain, M. J.
    Benedetti, F. M.
    Janisch, L.
    Khor, S.
    Schilsky, R. L.
    Cohen, E. E.
    Maitland, M. L.
    Elias, L.
    LoRusso, P. M.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [50] Phase II Results of Ara-C and Idarubicin in Combination with the Selective Inhibitor of Nuclear Export (SINE) Compound Selinexor (KPT-330) in Patients with Relapsed or Refractory AML
    Fiedler, Walter
    Heuser, Michael
    Chromik, Joerg
    Thol, Felicitas
    Bokemeyer, Carsten
    Theile, Susann
    Lebkuechner, Isabell
    Kranich, Anne L.
    BLOOD, 2016, 128 (22)