Mathematical Model of Electrotonic Interaction Between Mechanically Active Cardiomyocyte and Fibroblasts

被引：0
|
作者：
Bazhutina, Anastasia [1 ]
Balakina-Vikulova, Nathalie [2 ]
Solovyova, Olga [1 ]
Katsnelson, Leonid [2 ]
机构：
[1] Ural Fed Univ, Dept Math Mech & Comp Sci, Ekaterinburg, Russia
[2] Inst Immunol & Physiol, Lab Math Physiol, Ekaterinburg, Russia
来源：
2019 URAL SYMPOSIUM ON BIOMEDICAL ENGINEERING, RADIOELECTRONICS AND INFORMATION TECHNOLOGY (USBEREIT) | 2019年
基金：
俄罗斯基础研究基金会;
关键词：
cell models; fibroblasts; cardiac electromechanics; MYOCYTES;
D O I：
10.1109/usbereit.2019.8736669
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Cardiac fibroblasts are widely represented in mammalian cardiac tissue. These cells are connected with cardiomyocytes by gap junctions and they have own changeable membrane potential, so that fibroblasts can influence cardiomyocyte electrical activity. This effect may be analyzed in mathematical models. Existing mathematical models of fibroblast-cardiomyocyte interaction allow anyone to study only electrical responses of the cardiomyocytes and fibroblasts to their electrical interaction. In our work we have considered the fibroblast influence on the cardiomyocytes mechanics. In numerical experiments we reveal significant changes in the cardiomyocyte action potential duration and force depending on the number of fibroblast connected with the cardiomyocyte.
引用
收藏
页码：114 / 117
页数：4
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