Sensitivity of human adenoviruses to different groups of chemical biocides

被引:39
|
作者
Sauerbrei, A [1 ]
Sehr, K [1 ]
Brandstädt, A [1 ]
Heim, A [1 ]
Reimer, K [1 ]
Wutzler, P [1 ]
机构
[1] Univ Jena, Inst Virol & Antiviral Therapy, D-07745 Jena, Germany
关键词
human adenoviruses; chemical sensitivity; biocides; povidone-iodine; peracetic acid; formaldehyde;
D O I
10.1016/j.jhin.2004.01.022
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
As it is no longer readily permissible to propagate polioviruses, adenoviruses wilt probably become more frequently used for virucidal testing of broad-spectrum disinfectants. We tested prototype strains of different adenovirus serotypes belonging to the subgenera C and D for sensitivity to liposomal. povidone-iodine (PVP-I), peracetic acid (PAA) and formaldehyde. Virucidal assays were performed as suspension tests in accordance with the German guidelines for testing the effectiveness of chemical disinfectants against viruses. The sensitivity of the adenovirus serotypes to test disinfectants varied greatly. Prototype strains of adenovirus 5 and 44 statistically selected as 'little sensitive' to PVP-I, PAA and formaldehyde were found to be the most resistant. These might be suitable as model viruses for testing the broad-spectrum virucidal activity of disinfectants and might even replace the resistant poliovirus type 1. The main reason for the different chemical sensitivity of adenovirus serotypes may be the composition of the viral capsid proteins. Alternatively a different chemical inactivation of the viral genome could be involved. (C) 2004 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:59 / 66
页数:8
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