Proteome analysis to study signal transduction of G protein-coupled receptors

被引：14
|
作者：
Pluder, Franka [1 ]
Moerl, Karin [1 ]
Beck-Sickinger, Annette G. [1 ]
机构：
[1] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany
来源：
PHARMACOLOGY & THERAPEUTICS | 2006年 / 112卷 / 01期
关键词：
proteome analysis; G protein-coupled receptor;
D O I：
10.1016/j.pharmthera.2006.03.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR. (c) 2006 Elsevier Inc. All rights reserved.
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页码：1 / 11
页数：11
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