Proteome analysis to study signal transduction of G protein-coupled receptors

被引：14

作者：

Pluder, Franka ^{[1
]}

Moerl, Karin ^{[1
]}

Beck-Sickinger, Annette G. ^{[1
]}

机构：

[1] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany

来源：

PHARMACOLOGY & THERAPEUTICS | 2006年 / 112卷 / 01期

关键词：

proteome analysis; G protein-coupled receptor;

D O I：

10.1016/j.pharmthera.2006.03.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1 / 11

页数：11

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