Solid-phase synthesis of 2β-methyl substituted penam derivatives through penicillin sulfoxide rearrangement

被引：15

作者：

Delpiccolo, CML ^{[1
]}

Mata, EG ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis, RA-2000 Rosario, Santa Fe, Argentina

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(99)00440-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new, robust protocol for the solid-phase synthesis of 2 beta-methyl substituted penam derivatives is described. This synthetic sequence works reliably in good to high overall yields using Merrifield resin as support. The key step involves the thermal rearrangement of the corresponding penicillin sulfoxide. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3893 / 3897

页数：5

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