Voltammetric Determination of Phenylalanine Using Chemically Modified Screen-Printed Based Sensors

被引:13
|
作者
Dinu, Ancuta [1 ]
Apetrei, Constantin [1 ]
机构
[1] Dunarea de Jos Univ Galati, Fac Sci & Environm, Dept Chem Phys & Environm, 47 Domneasca St, Galati 800008, Romania
关键词
phenylalanine; sensor; Prussian Blue; cyclic voltammetry; electrochemistry; IMPRINTED ELECTROCHEMICAL SENSOR; PRUSSIAN BLUE; MELDOLAS BLUE; BETA-CYCLODEXTRIN; CARBON ELECTRODE; GOLD ELECTRODE; HPLC; DIAGNOSIS; TYROSINE; PHENYLKETONURIA;
D O I
10.3390/chemosensors8040113
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This paper describes the sensitive properties of screen-printed carbon electrodes (SPCE) modified by using three different electroactive chemical compounds: Meldola's Blue, Cobalt Phthalocyanine and Prussian Blue, respectively. It was demonstrated that the Prussian Blue (PB) modified SPCE presented electrochemical signals with the highest performances in terms of electrochemical process kinetics and sensitivity in all the solutions analyzed. PB-SPCE was demonstrated to detect Phe through the influence it exerts on the redox processes of PB. The PB-SPCE calibration have shown a linearity range of 0.33-14.5 mu M, a detection limit (LOD) of 1.23 x 10(-8) M and the standard deviation relative to 3%. The PB-SPCE sensor was used to determine Phe by means of calibration and standard addition techniques on pure samples, on simple pharmaceutical samples or on multicomponent pharmaceutical samples. Direct determination of the concentration of 4 x 10(-6)-5 x 10(-5) M Phe in KCl solution showed that the analytical recovery falls in the range of 99.75-100.28%, and relative standard deviations in the range of 2.28-3.02%. The sensors were successfully applied to determine the Phe in pharmaceuticals. The validation of the method was performed by using the FTIR, and by comparing the results obtained by PB-SPCE in the analysis of three pharmaceutical products of different concentrations with those indicated by the producer.
引用
收藏
页码:1 / 18
页数:18
相关论文
共 50 条
  • [1] Voltammetric Determination of Levodopa Using Mesoporous Carbon-Modified Screen-Printed Carbon Sensors
    Dascalescu, Dorin
    Apetrei, Constantin
    [J]. SENSORS, 2021, 21 (18)
  • [2] VOLTAMMETRIC BEHAVIOR OF SCREEN-PRINTED CARBON ELECTRODES, CHEMICALLY MODIFIED WITH SELECTED MEDIATORS, AND THEIR APPLICATION AS SENSORS FOR THE DETERMINATION OF REDUCED GLUTATHIONE
    WRING, SA
    HART, JP
    BIRCH, BJ
    [J]. ANALYST, 1991, 116 (02) : 123 - 129
  • [3] Voltammetric determination of doxycycline in feedstock using modified carbon screen-printed electrode
    M. S. Tiwari
    R. G. Thorat
    B. B. Popatkar
    V. V. Borge
    A. K. Kadu
    [J]. Analytical Sciences, 2023, 39 : 1889 - 1899
  • [4] Voltammetric determination of doxycycline in feedstock using modified carbon screen-printed electrode
    Tiwari, M. S.
    Thorat, R. G.
    Popatkar, B. B.
    Borge, V. V.
    Kadu, A. K.
    [J]. ANALYTICAL SCIENCES, 2023, 39 (11) : 1889 - 1899
  • [5] Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode
    Zhang, Yu
    Jiang, Xiantao
    Zhang, Junjie
    Zhang, Han
    Li, Yingchun
    [J]. BIOSENSORS & BIOELECTRONICS, 2019, 130 : 315 - 321
  • [6] Electrochemical Determination of Chlorogenic Acid in Nutraceuticals Using Voltammetric Sensors Based on Screen-Printed Carbon Electrode Modified with Graphene and Gold Nanoparticles
    Munteanu, Irina-Georgiana
    Apetrei, Constantin
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [7] Screen-Printed Disposable Sensors Modified with Bismuth Precursors for Rapid Voltammetric Determination of 3 Ecotoxic Nitrophenols
    Lezi, Nikolitsa
    Economou, Anastasios
    Barek, Jiri
    Prodromidis, Mamas
    [J]. ELECTROANALYSIS, 2014, 26 (04) : 766 - 775
  • [8] CHEMICALLY MODIFIED, SCREEN-PRINTED CARBON ELECTRODES
    WRING, SA
    HART, JP
    [J]. ANALYST, 1992, 117 (08) : 1281 - 1286
  • [9] Enhanced voltammetric determination of metal ions by using a bismuthene-modified screen-printed electrode
    Tapia, Maria A.
    Perez-Rafols, Clara
    Gusmao, Rui
    Serrano, Nuria
    Sofer, Zdenek
    Manuel Diaz-Cruz, Jose
    [J]. ELECTROCHIMICA ACTA, 2020, 362
  • [10] Antimony nanomaterials modified screen-printed electrodes for the voltammetric determination of metal ions
    Tapia, Maria A.
    Perez-Rafols, Clara
    Pastika, Jan
    Gusmao, Rui
    Serrano, Nuria
    Sofer, Zdenek
    Diaz-Cruz, Jose Manuel
    [J]. ELECTROCHIMICA ACTA, 2022, 425