Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

被引：31
|
作者：
Fernandez, Gabriela A. [1 ]
Vela Gurovic, Maria S. [1 ]
Olivera, Nelda L.
Chopa, Alicia B. [1 ]
Silbestri, Gustavo F. [1 ]
机构：
[1] Univ Natl Sur, Dept Quim, INQUISUR, Bahia Blanca, Buenos Aires, Argentina
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 135卷
关键词：
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial; ANTIMICROBIAL ACTIVITY; SILVER; AGENTS; RESISTANCE; TOXICITY; AG(I);
D O I：
10.1016/j.jinorgbio.2014.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：54 / 57
页数：4
相关论文
共 50 条
  • [41] In vitro Biological Activities of Gold(I) and Gold(III) Bis (N-Heterocyclic Carbene) Complexes
    Al-Majid, Abdullah M.
    Choudhary, Muhammad Iqbal
    Yousuf, Sammer
    Jabeen, Almas
    Imad, Rehan
    Javeed, Kulsoom
    Shaikh, Nimra Naveed
    Collado, Alba
    Sioriki, Eleni
    Nahra, Fady
    Nolan, Steven P.
    CHEMISTRYSELECT, 2017, 2 (19): : 5316 - 5320
  • [42] Synthesis of water-soluble metal-n-heterocyclic carbene complexes.
    Cooks, SM
    Moore, LM
    Shaughnessy, KH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U527 - U527
  • [43] Gold(i) N-heterocyclic carbene complexes with tunable electronic properties for sensitive colorimetric detection of glutathione
    Zhang, Yi-Fan
    Li, Xin
    Zhang, Heng
    Wang, Xi-Qiang
    Sun, Li-Ying
    Duan, Xiang-Long
    Han, Ying-Feng
    MATERIALS CHEMISTRY FRONTIERS, 2023, 7 (14) : 2880 - 2888
  • [44] Synthesis, structural characterization, and antibacterial activity of alkenyl functionalized imidazolium N-heterocyclic silver(I) and gold(I) carbene complexes
    Rojo-Gomez, Erik G.
    Zuno-Cruz, Francisco J.
    Sanchez-Cabrera, Gloria
    Carpio-Granillo, Mariana
    Gonzalez-Abrego, Daniel O.
    Coronel-Olivares, Claudia
    Alvarado-Rodriguez, Jose G.
    Rosales-Hoz, Maria J.
    INORGANICA CHIMICA ACTA, 2023, 555
  • [45] Dinuclear N-heterocyclic carbene copper(I) complexes
    Trose, Michael
    Nahra, Fady
    Cazin, Catherine S. J.
    COORDINATION CHEMISTRY REVIEWS, 2018, 355 : 380 - 403
  • [46] Labile Rhodium(I)-N-Heterocyclic Carbene Complexes
    Palacios, Laura
    Di Giuseppe, Andrea
    Opalinska, Anna
    Castarlenas, Ricardo
    Perez-Torrente, Jesus J.
    Lahoz, Fernando J.
    Oro, Luis A.
    ORGANOMETALLICS, 2013, 32 (09) : 2768 - 2774
  • [47] Synthesis and Structural Characterization of Water-Soluble Gold(I) N-Heterocyclic Carbene Complexes. An X-ray Absorption Fine Structure Spectroscopy (XAFS) Study
    Fernandez, Gabriela A.
    Picco, Agustin S.
    Ceolin, Marcelo R.
    Chopa, Alicia B.
    Silbestri, Gustavo F.
    ORGANOMETALLICS, 2013, 32 (21) : 6315 - 6323
  • [48] Rhodium(I)-(N-heterocyclic carbene)-diphosphine complexes
    Sun, Hongsui
    Yu, Xiao-Yan
    Marcazzan, Paolo
    Patrick, Brian O.
    James, Brian R.
    CANADIAN JOURNAL OF CHEMISTRY, 2009, 87 (09) : 1248 - 1254
  • [49] Protonated water-soluble N-heterocyclic carbene ruthenium(II) complexes: Synthesis, cytotoxic and DNA binding properties and molecular docking study
    Akkoc, Mitat
    Balcioglu, Sevgi
    Gurses, Canbolat
    Tok, Tugba Taskin
    Ates, Burhan
    Yasar, Sedat
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2018, 869 : 67 - 74
  • [50] Facile Synthesis of (Phosphine)- and (N-heterocyclic Carbene)Gold(I) and Silver(I) Azide Complexes
    Partyka, David V.
    Robilotto, Thomas J.
    Updegraff, James B., III
    Zeller, Matthias
    Hunter, Allen D.
    Gray, Thomas G.
    ORGANOMETALLICS, 2009, 28 (03) : 795 - 801
12345