Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

被引：31
|
作者：
Fernandez, Gabriela A. [1 ]
Vela Gurovic, Maria S. [1 ]
Olivera, Nelda L.
Chopa, Alicia B. [1 ]
Silbestri, Gustavo F. [1 ]
机构：
[1] Univ Natl Sur, Dept Quim, INQUISUR, Bahia Blanca, Buenos Aires, Argentina
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 135卷
关键词：
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial; ANTIMICROBIAL ACTIVITY; SILVER; AGENTS; RESISTANCE; TOXICITY; AG(I);
D O I：
10.1016/j.jinorgbio.2014.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：54 / 57
页数：4
相关论文
共 50 条
  • [1] Robust Water-Soluble Gold Nanoparticles via Polymerized Mesoionic N-Heterocyclic Carbene-Gold(I) Complexes
    Nguyen, Diep T. H.
    Belanger-Bouliga, Marilyne
    Shultz, Lorianne R.
    Maity, Arunava
    Jurca, Titel
    Nazemi, Ali
    CHEMISTRY OF MATERIALS, 2021, 33 (24) : 9588 - 9600
  • [2] Photoluminescence properties of Gold(I)-N-Heterocyclic carbene complexes
    Hussaini, Sunusi Y.
    Razali, Mohd R.
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1322
  • [3] Synthesis and catalytic properties of new water-soluble ruthenium(II)-N-heterocyclic carbene complexes
    Csabai, P
    Joó, F
    ORGANOMETALLICS, 2004, 23 (23) : 5640 - 5643
  • [4] Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols
    Fernandes, Ana
    Royo, Beatriz
    CHEMCATCHEM, 2017, 9 (20) : 3912 - 3917
  • [5] Synthesis of N-heterocyclic carbene gold(I) complexes
    Fady Nahra
    Nikolaos V. Tzouras
    Alba Collado
    Steven P. Nolan
    Nature Protocols, 2021, 16 : 1476 - 1493
  • [6] Gold(I) N-heterocyclic carbene and carbazolate complexes
    Wang, HAJ
    Vasam, CS
    Tsai, TYR
    Chen, SH
    Chang, AHH
    Lin, IJB
    ORGANOMETALLICS, 2005, 24 (04) : 486 - 493
  • [7] Synthesis of N-heterocyclic carbene gold(I) complexes
    Nahra, Fady
    Tzouras, Nikolaos, V
    Collado, Alba
    Nolan, Steven P.
    NATURE PROTOCOLS, 2021, 16 (03) : 1476 - 1493
  • [8] Synthesis and properties of water soluble N-heterocyclic carbene dinitrosyl iron complexes
    Chupik, Rachel B.
    Pulukkody, Randara
    Darensbourg, Marcetta Y.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [9] Anticancer properties of gold(I)-N-heterocyclic carbene complexes and their silver(I) precursors
    Siciliano, Tammy J.
    Deblock, Michael C.
    Hindi, Khadijah M.
    Durmus, Semih
    Panzner, Matthew J.
    Tessier, Claire A.
    Youngs, Wiley J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [10] Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes
    Siciliano, Tammy J.
    Deblock, Michael C.
    Hindi, Khadijah M.
    Durmus, Semih
    Panzner, Matthew J.
    Tessier, Claire A.
    Youngs, Wiley J.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (05) : 1066 - 1071
12345