Early Diagnosis of Pancreatic Cancer: The Key for Survival

被引：52

作者：

Gheorghe, Gina ^{[1
,2
]}

Bungau, Simona ^{[3
]}

Ilie, Madalina ^{[1
,4
]}

Behl, Tapan ^{[5
]}

Vesa, Cosmin Mihai ^{[6
]}

Brisc, Ciprian ^{[7
]}

Bacalbasa, Nicolae ^{[8
,9
]}

Turi, Vladiana ^{[10
]}

Costache, Raluca Simona ^{[1
,11
]}

Diaconu, Camelia Cristina ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Dept 5, Bucharest 050474, Romania

[2] Clin Emergency Hosp Bucharest, Dept Internal Med, Bucharest 105402, Romania

[3] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania

[4] Clin Emergency Hosp Bucharest, Dept Gastroenterol, Bucharest 105402, Romania

[5] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India

[6] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410041, Romania

[7] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410041, Romania

[8] Ion Cantacuzino Clin Hosp, Dept Surg, Bucharest 030167, Romania

[9] Carol Davila Univ Med & Pharm, Dept 13, Bucharest 050474, Romania

[10] Victor Babes Univ Med & Pharm, Dept Cardiol, Timisoara 300041, Romania

[11] Carol Davila Univ, Dept Gastroenterol, Emergency Cent Mil Hosp, Bucharest 010825, Romania

来源：

DIAGNOSTICS | 2020年 / 10卷 / 11期

关键词：

pancreatic cancer; carbohydrate antigen 19-9 (CA19.9); risk factors; early diagnosis; biomarkers; HELICOBACTER-PYLORI SEROPOSITIVITY; ENDOSCOPIC ULTRASOUND ELASTOGRAPHY; HIGH-RISK INDIVIDUALS; DIABETES-MELLITUS; COMPUTED-TOMOGRAPHY; PROSPECTIVE-COHORT; CIGARETTE-SMOKING; SERUM BIOMARKER; POOLED ANALYSIS; GENE-MUTATIONS;

D O I：

10.3390/diagnostics10110869

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is mainly due to the late diagnosis in advanced stages, when the disease is already therapeutically overcome. Studies in recent years have focused on identifying biomarkers that could play a role in early diagnosis, leading to the improvement of morbidity and mortality. Currently, the only biomarker widely used in the diagnosis of PC is carbohydrate antigen 19-9 (CA19.9), which has, however, more of a prognostic role in the follow-up of postoperative recurrence than a diagnostic role. Other biomarkers, recently identified as the methylation status of ADAMTS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) and BNC1 (zinc finger protein basonuclin-1) in cell-free deoxyribonucleic acid (DNA), may play a role in the early detection of PC. This review focuses on the diagnosis of PC in its early stages.

引用

页数：17

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