Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

被引：11
|
作者：
Gunosewoyo, Hendra [1 ,2 ]
Coster, Mark J. [3 ]
Bennett, Maxwell R. [2 ]
Kassiou, Michael [1 ,2 ,4 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
[2] Brain & Mind Res Inst, Sydney, NSW 2050, Australia
[3] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia
[4] Univ Sydney, Discipline Med Radiat Sci, Sydney, NSW 2006, Australia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 14期
关键词：
P2X7; antagonists; Cytokine release; Rational drug design; LL-37; IN-VITRO ACTIVITY; INTERLEUKIN-1-BETA RELEASE; POLYMYXIN-B; POTENT; DISCOVERY; PEPTIDE; LL-37; PAIN; TAIL;
D O I：
10.1016/j.bmc.2009.05.083
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：4861 / 4865
页数：5
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