Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues

被引：21
|
作者：
Burlingame, MA
Shaw, SJ
Sundermann, KF
Zhang, D
Petryka, J
Mendoza, E
Liu, FH
Myles, DC
LaMarche, MJ
Hirose, T
Freeze, BS
Smith, AB
机构：
[1] Kosan Biosci Inc, Dept Chem, Hayward, CA 94545 USA
[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期
关键词：
discodermolide;
D O I：
10.1016/j.bmcl.2004.01.102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2335 / 2338
页数：4
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