Phagocytic activity and state of bactericidal systems in polymorphonuclear leukocytes from patients with Alzheimer's disease

被引：15
|
作者：
Davydova, TV [1 ]
Fomina, VG
Voskresenskaya, NI
Doronina, OA
机构：
[1] RAS, Inst Gen Pathol & Pathophysiol, Moscow, Russia
[2] Russian Acad Med Sci, State Res Ctr Mental Hlth, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 04期
关键词：
Alzheimer's disease; neutrophils; phagocytosis; myeloperoxidase; cationic proteins;
D O I：
10.1023/B:BEBM.0000010950.53560.e2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Phagocytic activity of peripheral blood neutrophils underwent phase changes in patients with Alzheimer's disease. Neutrophils retained the ability to engulf microbes, but their digestive activity decreased at the early stage of Alzheimer's disease. At the. late stage we observed a decrease in the count of phagocytizing neutrophils, reduction of myeloperoxidase activity, and increase in the content of cationic proteins.
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页码：355 / 357
页数：3
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