Discovery of mutant IDH2 inhibitors for the treatment of cancer

被引：0
|
作者：
Travins, Jeremy M. [1 ]
Popovici-Muller, Janeta [1 ]
DeLaBarre, Byron [2 ]
Gross, Stefan [2 ]
Yang, Hua [4 ]
Wang, Fang [3 ]
Yen, Katherine E. [3 ]
Salituro, Francesco G. [1 ]
Saunders, Jeffrey O. [1 ]
Dang, Lenny [2 ]
Biller, Scott A. [1 ]
机构：
[1] Agios Pharmaceut, Dept Chem, Cambridge, MA 02139 USA
[2] Agios Pharmaceut, Dept Biochem, Cambridge, MA 02139 USA
[3] Agios Pharmaceut, Dept Biol, Cambridge, MA 02139 USA
[4] Agios Pharmaceut, Dept Drug Metab & Pharmacokinet, Cambridge, MA 02139 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 246卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
200-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Cancer-associated IDH1 and IDH2 mutations: therapeutic opportunities
    Jin, S.
    Dang, L.
    Gross, S.
    Driggers, E.
    Yen, K.
    Bittinger, M.
    Thompson, C.
    Cantley, L.
    Su, M.
    Fantin, V.
    EJC SUPPLEMENTS, 2010, 8 (07): : 56 - 56
  • [42] Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer
    Matthias Holdhoff
    D. Williams Parsons
    Luis A. Diaz
    Journal of Neuro-Oncology, 2009, 94 : 297 - 297
  • [43] IDH1 and IDH2 Mutations in Gliomas
    Ducray, Francois
    Marie, Yannick
    Sanson, Marc
    NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (21): : 2248 - 2249
  • [44] IDH1 and IDH2 Mutations in Gliomas
    Cohen, Adam L.
    Holmen, Sheri L.
    Colman, Howard
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2013, 13 (05)
  • [45] IDH1 and IDH2 Mutations in Gliomas
    Yan, Hai
    Parsons, D. Williams
    Jin, Genglin
    McLendon, Roger
    Rasheed, B. Ahmed
    Yuan, Weishi
    Kos, Ivan
    Batinic-Haberle, Ines
    Jones, Sian
    Riggins, Gregory J.
    Friedman, Henry
    Friedman, Allan
    Reardon, David
    Herndon, James
    Kinzler, Kenneth W.
    Velculescu, Victor E.
    Vogelstein, Bert
    Bigner, Darell D.
    NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (08): : 765 - 773
  • [46] Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2
    Ma, Rui
    Yun, Cai-Hong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 503 (04) : 2912 - 2917
  • [47] Design, synthesis, AML activity and molecular modeling of novel IDH2 inhibitors
    Jin, Ruyi
    Tang, Tian
    Zhou, Sha
    Tang, Yuping
    Guo, Hui
    Wang, Yuwei
    Nie, Fayi
    BIOORGANIC CHEMISTRY, 2023, 130
  • [48] Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
    Chen, Dong
    Xia, Siyuan
    Zhang, Rukang
    Li, Yuancheng
    Famulare, Christopher A.
    Fan, Hao
    Wu, Rong
    Wang, Mei
    Zhu, Allen C.
    Elf, Shannon E.
    Su, Rui
    Dong, Lei
    Arellano, Martha
    Blum, William G.
    Mao, Hui
    Lonial, Sagar
    Stock, Wendy
    Odenike, Olatoyosi
    Le Beau, Michelle
    Boggon, Titus J.
    He, Chuan
    Chen, Jianjun
    Gao, Xue
    Levine, Ross L.
    Chen, Jing
    MOLECULAR CELL, 2021, 81 (18) : 3833 - +
  • [49] Teenage mutant neutrophilic precursors: Leukemia cutis with IDH2 mutation on enasidenib therapy
    Kallen, Michael E.
    Koka, Rima
    Singh, Zeba
    Sanchez-Petitto, Gabriela
    Zaman, Qamar U.
    Yared, Jean A.
    Duong, Vu H.
    LEUKEMIA RESEARCH, 2020, 96
  • [50] D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice
    Akbay, Esra A.
    Moslehi, Javid
    Christensen, Camilla L.
    Saha, Supriya
    Tchaicha, Jeremy H.
    Ramkissoon, Shakti H.
    Stewart, Kelly M.
    Carretero, Julian
    Kikuchi, Eiki
    Zhang, Haikuo
    Cohoon, Travis J.
    Murray, Stuart
    Liu, Wei
    Uno, Kazumasa
    Fisch, Sudeshna
    Jones, Kristen
    Gurumurthy, Sushma
    Gliser, Camelia
    Choe, Sung
    Keenan, Marie
    Son, Jaekyoung
    Stanley, Illana
    Losman, Julie A.
    Padera, Robert
    Bronson, Roderick T.
    Asara, John M.
    Abdel-Wahab, Omar
    Amrein, Philip C.
    Fathi, Amir T.
    Danial, Nika N.
    Kimmelman, Alec C.
    Kung, Andrew L.
    Ligon, Keith L.
    Yen, Katharine E.
    Kaelin, William G., Jr.
    Bardeesy, Nabeel
    Wong, Kwok-Kin
    GENES & DEVELOPMENT, 2014, 28 (05) : 479 - 490
12345