Rheumatic Fever: A Model of Autoimmune Disease due to Molecular Mimicry between Human and Pathogen Proteins

被引：2

作者：

Kalil, Jorge ^{[1
,2
,3
]}

Guilherme, Luiza ^{[1
,2
,3
]}

机构：

[1] Univ Sao Paulo, Clin Hosp, Dept Clin Med, Sao Paulo, Brazil

[2] Univ Sao Paulo, Heart Inst InCor, Sch Med, Sao Paulo, Brazil

[3] Millennium Inst, Inst Immunol Invest, Sao Paulo, Brazil

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2020年 / 40卷 / 05期

关键词：

S; pyogenes; throat infection; heart tissue; valves; molecular mimicry; HEART-DISEASE; RECOGNIZE; TISSUE; CELLS;

D O I：

10.1615/CritRevImmunol.2020035024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute rheumatic fever (ARF) is caused by an autoimmune response to throat infection with Streptococcus pyogenes in individuals who present some susceptibility genes. Rheumatic heart disease (RHD) is the major sequela and can cause heart failure and premature mortality. The disease is mediated by humoral and cellular immune responses. In this review, we present the major events that can trigger heart lesions.

引用

页码：419 / 422

页数：4

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