Molecular mechanisms of Bcr-Abl-induced oncogenesis

被引：0
|
作者：
Gishizky, ML
机构：
来源：
CYTOKINES AND MOLECULAR THERAPY | 1996年 / 2卷 / 04期
关键词：
Bcr-Abl; chronic myelogenous leukemia; signal transduction; adaptor proteins; Grb2; shc; CrkL; tyrosine kinase;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The chimeric Bcr-Abl oncogene has been implicated in the pathogenesis of chronic myelogenous leukemia (CML) and Philadelphia chromosome (Ph1)-positive acute lymphocytic leukemia (ALL). The Bcr-Abl protein is a complex structure comprising discrete domains associated with specific biochemical and biological functions. These domains function through their ability to activate distinct signal transduction pathways responsible for Bcr-Abl's oncogenic behavior. This review will present our current understanding of signal transduction pathways involved in Bcr-Abl-induced pathophysiology, with particular emphasis on potential targets for therapeutic intervention.
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页码：251 / 261
页数：11
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