Isolated antibodies against the core antigen of hepatitis B virus in HIV-infected patients

被引：30
|
作者：
Neau, D
Winnock, M
Galpérine, T
Jouvencel, AC
Castéra, L
Legrand, E
Tranchant, E
Balestre, E
Lacoste, D
Ragnaud, JM
Dupon, M
Lafon, ME
Dabis, F
机构：
[1] Hop Pellegrin, Federat Infect & Trop Dis, F-33076 Bordeaux, France
[2] Victor Segalen Univ, INSERM, U593, ISPED, Bordeaux, France
[3] Hop Pellegrin, Dept Virol, F-33076 Bordeaux, France
[4] St Andre Hosp, Hepato Gastroenterol Dept, Bordeaux, France
[5] Haut Leveque Hosp, Pessac, France
[6] St Andre Hosp, Federat Internal Med & Infect Dis, Bordeaux, France
来源：
HIV MEDICINE | 2004年 / 5卷 / 03期
关键词：
HCV coinfection; hepatitis B virus; isolated anti-HBc antibodies; occult HBV infection;
D O I：
10.1111/j.1468-1293.2004.00206.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The aim of this study was to describe the frequency and significance of isolated antibodies against the hepatitis B virus (HBV) core antigen (HBc) in 2185 HIV-infected patients of the Aquitaine Cohort. Antibodies against HBc were found in 372 subjects (17%). Patients with isolated anti-HBc antibodies were more frequently coinfected with hepatitis C virus (HCV) (58.2%) than those who were anti-HB surface (HBs) antibody positive (22.9%, P<0.001) and those who were dually reactive anti-HBs/anti-HBc antibody positive (27.3%, P<0.001). These results suggest interactions between HBV and HCV. As observed in patients not infected with HIV, the 'anti-HBc-alone' serological profile could reflect essentially late immunity with undetectable anti-HBs antibodies. However, an occult HBV infection cannot be ruled out.
引用
收藏
页码：171 / 173
页数：3
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