Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide

被引：38
|
作者：
Reffuveille, Fany [1 ]
de la Fuente-Nunez, Cesar [1 ]
Fairfull-Smith, Kathryn E. [2 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Dept Microbiol & Immunol, 232-2259 Lower Mall Res Stn, Vancouver, BC V6T 1Z4, Canada
[2] Queensland Univ Technol, Fac Sci & Engn, ARC Ctr Excellence Free Rad Chem & Biotechnol, Brisbane, Qld 4001, Australia
来源：
PATHOGENS AND DISEASE | 2015年 / 73卷 / 05期
基金：
澳大利亚研究理事会;
关键词：
biofilm; nitroxide; ciprofloxacin; NITRIC-OXIDE; DISPERSAL;
D O I：
10.1093/femspd/ftv016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We previously showed that soluble nitroxides (nitric oxide analogues) mimicked the well-established ability of nitric oxide to cause biofilm dispersal and further showed that these compounds could prevent biofilm formation. Here, we investigated the effect of the nitroxide carboxy-TEMPO in combination with sub mu g/ml concentrations of ciprofloxacin on pre-formed flow cell biofilms formed by Gram-negative bacteria. Combination therapy led to substantial eradication of existing biofilms formed by Pseudomonas aeruginosa PA14 (99.3%) and Escherichia coli O157 (93%).
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页数：4
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