Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide

被引：38
|
作者：
Reffuveille, Fany [1 ]
de la Fuente-Nunez, Cesar [1 ]
Fairfull-Smith, Kathryn E. [2 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Dept Microbiol & Immunol, 232-2259 Lower Mall Res Stn, Vancouver, BC V6T 1Z4, Canada
[2] Queensland Univ Technol, Fac Sci & Engn, ARC Ctr Excellence Free Rad Chem & Biotechnol, Brisbane, Qld 4001, Australia
来源：
PATHOGENS AND DISEASE | 2015年 / 73卷 / 05期
基金：
澳大利亚研究理事会;
关键词：
biofilm; nitroxide; ciprofloxacin; NITRIC-OXIDE; DISPERSAL;
D O I：
10.1093/femspd/ftv016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We previously showed that soluble nitroxides (nitric oxide analogues) mimicked the well-established ability of nitric oxide to cause biofilm dispersal and further showed that these compounds could prevent biofilm formation. Here, we investigated the effect of the nitroxide carboxy-TEMPO in combination with sub mu g/ml concentrations of ciprofloxacin on pre-formed flow cell biofilms formed by Gram-negative bacteria. Combination therapy led to substantial eradication of existing biofilms formed by Pseudomonas aeruginosa PA14 (99.3%) and Escherichia coli O157 (93%).
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Treatment of Gram-negative bacterial infections by potentiation of antibiotics
    Zabawa, Thomas P.
    Pucci, Michael J.
    Parr, Thomas R., Jr.
    Lister, Troy
    CURRENT OPINION IN MICROBIOLOGY, 2016, 33 : 7 - 12
  • [2] Antibiofilm activity of Fmoc-phenylalanine against Gram-positive and Gram-negative bacterial biofilms
    Himanshi Singh
    Avinash Gahane
    Virender Singh
    Shreya Ghosh
    Ashwani Thakur
    The Journal of Antibiotics, 2021, 74 : 407 - 416
  • [3] Antibiofilm activity of Fmoc-phenylalanine against Gram-positive and Gram-negative bacterial biofilms
    Singh, Himanshi
    Gahane, Avinash
    Singh, Virender
    Ghosh, Shreya
    Thakur, Ashwani
    JOURNAL OF ANTIBIOTICS, 2021, 74 (06): : 407 - 416
  • [4] INVITRO ACTIVITY OF CIPROFLOXACIN AGAINST AEROBIC GRAM-NEGATIVE BACTERIA
    RUDIN, JE
    NORDEN, CW
    SHINNERS, EM
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 26 (04) : 597 - 598
  • [5] The effect of piscidin antimicrobial peptides on the formation of Gram-negative bacterial biofilms
    Prior, Benjamin S.
    Lange, Miles D.
    Salger, Scott A.
    Reading, Benjamin J.
    Peatman, Eric
    Beck, Benjamin H.
    JOURNAL OF FISH DISEASES, 2022, 45 (01) : 99 - 105
  • [6] POSTANTIBIOTIC SUPPRESSIVE EFFECT OF CIPROFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
    CHIN, NX
    NEU, HC
    AMERICAN JOURNAL OF MEDICINE, 1987, 82 (4A): : 58 - 62
  • [7] Current Activity of Ciprofloxacin Against Gram-Negative Bacilli in the United States
    C. Thornsberry
    M. K. Marsilio
    M. E. Jones
    K. M. Tomfohrde
    B. H. Heller
    G. Piazza
    Daniel F. Sahm
    Drugs, 1999, 58 : 186 - 187
  • [8] Current activity of ciprofloxacin against Gram-negative bacilli in the United States
    Thornsberry, C
    Marsilio, MK
    Jones, ME
    Tomfohrde, KM
    Heller, BH
    Piazza, G
    Sahm, DF
    DRUGS, 1999, 58 (Suppl 2) : 186 - 187
  • [9] SYNERGISM BETWEEN CIPROFLOXACIN AND FOSFOMYCIN AGAINST GRAM-NEGATIVE BACTERIA INVITRO
    VOGT, K
    HAHN, H
    ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES, 1989, 272 (02): : 225 - 230
  • [10] Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens
    Zlamal, Jaime E.
    Leyn, Semen A.
    Iyer, Mallika
    Elane, Marinela L.
    Wong, Nicholas A.
    Wamsley, James W.
    Vercruysse, Maarten
    Garcia-Alcalde, Fernando
    Osterman, Andrei L.
    MBIO, 2021, 12 (03):
12345