Synthesis, characterization, photocleavage of DNA and cytotoxicity of ruthenium(II) mixed-ligand complexes

被引：21
|
作者：
Liu, Yun-Jun [1 ]
Zeng, Cheng-Hui [1 ]
Wu, Fu-Hai [2 ]
Yao, Jun-Hua [3 ]
He, Li-Xin [1 ]
Huang, Hong-Liang [4 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R China
[4] Guangdong Pharmaceut Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2009年 / 932卷 / 1-3期
关键词：
Ruthenium(II) complex; Photocleavage; Cytotoxicity; DOUBLE-HELICAL DNA; DEOXYRIBONUCLEIC-ACID; BINDING; OXIDATION; 2,2-BIPYRIDINE; RECOGNITION; COBALT(III); CLEAVAGE; SPECTRA;
D O I：
10.1016/j.molstruc.2009.05.046
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Two new ruthenium(II) polypyridyl complexes [Ru(dmb)(2)(Fpp)](ClO4)(2) 1 (Fpp=2-(3',3'-difluoro-3,4-methylenedioxyphenyl)imidazo[4,5-f][1,10]phenanthroline, dmb = 4,4'-dimethyl-2,2'-bipyridine) and [Ru(bpy)(2)(Fpp)](ClO4)(2) 2 (bpy = 2,2'-bipyridine) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS, IR, H-1 NMR and C-13 NMR. The DNA-binding behaviors of these complexes were investigated by absorption spectroscopic titration, viscosity measurements, thermal denaturation and photocleavage. The mechanism studies of photocleavage reveal that singlet oxygen (O-1(2)) and superoxide anion radical (O-2(center dot-)) May play an important role in the photocleavage. The cytotoxicity of complexes 1 and 2 have been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 111
页数：7
相关论文
共 50 条
  • [21] Mixed-ligand complexes of ruthenium(II) containing new photoactive or electroactive ligands: synthesis, spectral characterization and DNA interactions
    Tamal Ghosh
    Bhaskar G. Maiya
    Anunay Samanta
    Atindra D. Shukla
    D. Amilan Jose
    D. Krishna Kumar
    Amitava Das
    [J]. JBIC Journal of Biological Inorganic Chemistry, 2005, 10 : 496 - 508
  • [22] SYNTHESIS AND CHARACTERIZATION OF NEW MIXED-LIGAND COMPLEXES OF RUTHENIUM(II) CONTAINING TRIPHENYLPHOSPHINE AND 2'-HYDROXYCHALCONES
    DHARMARAJ, N
    NATARAJAN, K
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1994, 33 (08): : 785 - 787
  • [23] Synthesis, characterization, DNA-binding, photocleavage, cytotoxicity and docking studies of Co(III) mixed ligand complexes
    Kumar, Yata Praveen
    Devi, C. Shobha
    Deepika, N.
    Gabra, Nazar M. D.
    Jain, Nishant
    Srishailam, A.
    Reddy, Kotha Laxma
    Satyanarayana, S.
    [J]. TRANSITION METAL CHEMISTRY, 2013, 38 (08) : 811 - 819
  • [24] DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes
    Yi-fan Du
    Jia-Zheng Lu
    Hai-wei Guo
    Jing Jiang
    Ping Chao
    Fei Chen
    Jie-Ming Pan
    [J]. Transition Metal Chemistry, 2010, 35 : 859 - 864
  • [25] DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes
    Du, Yi-fan
    Lu, Jia-Zheng
    Guo, Hai-wei
    Jiang, Jing
    Chao, Ping
    Chen, Fei
    Pan, Jie-Ming
    [J]. TRANSITION METAL CHEMISTRY, 2010, 35 (07) : 859 - 864
  • [26] Synthesis, characterization, DNA-binding, photocleavage, cytotoxicity and docking studies of Co(III) mixed ligand complexes
    Yata Praveen Kumar
    C. Shobha Devi
    N. Deepika
    Nazar MD Gabra
    Nishant Jain
    A. Srishailam
    Kotha Laxma Reddy
    S. Satyanarayana
    [J]. Transition Metal Chemistry, 2013, 38 : 811 - 819
  • [27] Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand
    Liu, Xue-Wen
    Li, Lin
    Lu, Ji-Lin
    Chen, Yuan-Dao
    Zhang, Da-Shun
    [J]. JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (24) : 4344 - 4356
  • [28] Noncovalent DNA binding and nuclease activity of mixed-ligand ruthenium(II) complexes
    Iizuka, Naho
    Nakai, Misaki
    Nakabayashi, Yasuo
    [J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S788 - S788
  • [29] DNA-binding studies of mixed-ligand (ethylenediamine)ruthenium(II) complexes
    Nagababu, Penumaka
    Latha, J. Naveena Lavanya
    Satyanarayana, Sirasani
    [J]. CHEMISTRY & BIODIVERSITY, 2006, 3 (11) : 1219 - 1229
  • [30] MIXED-LIGAND COMPLEXES OF RUTHENIUM(II) WITH HETEROCYCLIC DITHIOCARBAMATES
    CHINNUSAMY, V
    NATARAJAN, K
    [J]. SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 1993, 23 (05): : 745 - 756
12345