Synthesis, characterization, photocleavage of DNA and cytotoxicity of ruthenium(II) mixed-ligand complexes

被引：21
|
作者：
Liu, Yun-Jun [1 ]
Zeng, Cheng-Hui [1 ]
Wu, Fu-Hai [2 ]
Yao, Jun-Hua [3 ]
He, Li-Xin [1 ]
Huang, Hong-Liang [4 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R China
[4] Guangdong Pharmaceut Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2009年 / 932卷 / 1-3期
关键词：
Ruthenium(II) complex; Photocleavage; Cytotoxicity; DOUBLE-HELICAL DNA; DEOXYRIBONUCLEIC-ACID; BINDING; OXIDATION; 2,2-BIPYRIDINE; RECOGNITION; COBALT(III); CLEAVAGE; SPECTRA;
D O I：
10.1016/j.molstruc.2009.05.046
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Two new ruthenium(II) polypyridyl complexes [Ru(dmb)(2)(Fpp)](ClO4)(2) 1 (Fpp=2-(3',3'-difluoro-3,4-methylenedioxyphenyl)imidazo[4,5-f][1,10]phenanthroline, dmb = 4,4'-dimethyl-2,2'-bipyridine) and [Ru(bpy)(2)(Fpp)](ClO4)(2) 2 (bpy = 2,2'-bipyridine) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS, IR, H-1 NMR and C-13 NMR. The DNA-binding behaviors of these complexes were investigated by absorption spectroscopic titration, viscosity measurements, thermal denaturation and photocleavage. The mechanism studies of photocleavage reveal that singlet oxygen (O-1(2)) and superoxide anion radical (O-2(center dot-)) May play an important role in the photocleavage. The cytotoxicity of complexes 1 and 2 have been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 111
页数：7
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