TRIM proteins form a protein family that is characterized by a conserved tripartite motif domain comprising a RING domain, one or two B-box domains and a coiled-coil region. Members of this large protein family are important regulators of numerous cellular functions including innate immune responses, transcriptional regulation and apoptosis. Key to their cellular role is their E3 ligase activity which is conferred by the RING domain. Self-association is art important characteristic of TRIM protein activity and is mediated by homodimerization via the coiled-coil region, and in some cases higher order association via additional domains of the tripartite motif. In many of the TRIM family proteins studied thus far, RING dimerization is an important prerequisite for E3 ligase enzymatic activi though the propensity of RING domains to dimerize differs significantly between different TRIMs and can be influenced by other regions of the protein.
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Fudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R ChinaFudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China
Duan, Zhijian
Gao, Bo
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Fudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R ChinaFudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China
Gao, Bo
Xu, Wei
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Fudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R ChinaFudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China
Xu, Wei
Xiong, Sidong
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Fudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China
E Inst Shanghai Univ, Div Immunol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China
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Southwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R ChinaSouthwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R China
Bian, Weixiang
Guo, Yanmin
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Southwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R ChinaSouthwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R China
Guo, Yanmin
Zhang, Yuan
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Southwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R ChinaSouthwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R China
Zhang, Yuan
Li, Hongtao
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Southwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R ChinaSouthwest Univ, State Key Lab Breeding Base Bioresources & Ecoenv, Lab Mol Dev Biol,Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R China