Synthesis and biological evaluation of bryostatin analogues: the role of the A-ring

被引：36

作者：

Wender, PA ^{[1
]}

Lippa, B ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)02195-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first biologically active member and a key intermediate of a new family of simplified bryostatin analogues are synthesized through an optimized esterification-macrotransacetalization strategy. This family incorporates both an ester linkage between C5 and C9 in addition to a C9 t-butyl substituent to mimic the bryostatin A-ring. Importantly, a free C7 alcohol is revealed late in the synthesis, allowing access to numerous C7 derivatized analogues. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1007 / 1011

页数：5

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