Synthesis and biological evaluation of bryostatin analogues: the role of the A-ring

被引：36
|
作者：
Wender, PA [1 ]
Lippa, B [1 ]
机构：
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 07期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0040-4039(99)02195-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first biologically active member and a key intermediate of a new family of simplified bryostatin analogues are synthesized through an optimized esterification-macrotransacetalization strategy. This family incorporates both an ester linkage between C5 and C9 in addition to a C9 t-butyl substituent to mimic the bryostatin A-ring. Importantly, a free C7 alcohol is revealed late in the synthesis, allowing access to numerous C7 derivatized analogues. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1007 / 1011
页数：5
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