Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists

被引：20
|
作者：
Zhang, Jinfeng [1 ,2 ]
Yan, Wenzhong [1 ]
Duan, Wenwen [1 ]
Wuthrich, Kurt [1 ,3 ]
Cheng, Jianjun [1 ]
机构：
[1] ShanghaiTech Univ, IHuman Inst, Shanghai 201210, Peoples R China
[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
[3] Scripps Res, Dept Integrated Struct & Computat Biol, La Jolla, CA 92037 USA
来源：
PHARMACEUTICALS | 2020年 / 13卷 / 09期
关键词：
GPCR; immuno-oncology; Parkinson's disease; drug binding modes; cancer therapy; PARKINSONS-DISEASE; CRYSTAL-STRUCTURE; DERIVATIVES; ZM241385; POTENT; ZM-241385; BLOCKADE; BINDING; CELLS;
D O I：
10.3390/ph13090237
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The A(2A) adenosine receptor (A(2A) AR) plays critical roles in human physiology and pathophysiology, which makes it an important drug target. Previous drug-discovery efforts targeting the A(2A) AR have been focused on the use of A(2A) AR antagonists for the treatment of Parkinson's disease. More recently, the A(2A) AR has attracted additional attention for its roles in immuno-oncology, and a number of A(2A) AR antagonists are currently used as lead compounds for antitumor drugs in both preclinical models and clinical trials. This review surveys recent advances in the development of A(2A) AR antagonists for cancer immunotherapy. The therapeutic potential of representative A(2A) AR antagonists is discussed based on both animal efficacy studies and clinical data.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 50 条
  • [31] Evaluation of analogues of (-)-mefloquine as adenosine A2A receptor antagonists.
    Gillespie, RJ
    Giles, PR
    Lerpiniere, J
    Ward, SE
    Weiss, SM
    Knight, TR
    Misra, A
    Benwell, K
    Dourish, CT
    Cliffe, IA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U51 - U51
  • [32] A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?
    Spinaci, Andrea
    Lambertucci, Catia
    Buccioni, Michela
    Dal Ben, Diego
    Graiff, Claudia
    Barbalace, Maria Cristina
    Hrelia, Silvana
    Angeloni, Cristina
    Tayebati, Seyed Khosrow
    Ubaldi, Massimo
    Masi, Alessio
    Klotz, Karl-Norbert
    Volpini, Rosaria
    Marucci, Gabriella
    MOLECULES, 2022, 27 (08):
  • [33] An Overview of Adenosine A2A Receptor Antagonists in Parkinson's Disease
    Jenner, Peter
    ADENOSINE RECEPTORS IN NEUROLOGY AND PSYCHIATRY, 2014, 119 : 71 - 86
  • [34] Synthesis and biological evaluation of adenosine A2A receptor antagonists.
    Caldwell, J
    Matasi, J
    Tulshian, D
    Arik, L
    Fawzi, A
    Foster, C
    Isaac, LK
    Lachowicz, J
    Zhang, HT
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U919 - U919
  • [35] Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists
    Franco, Rafael
    Reyes-Resina, Irene
    Aguinaga, David
    Lillo, Alejandro
    Jimenez, Jasmina
    Raich, Iu
    Borroto-Escuela, Dasiel O.
    Ferreiro-Vera, Carlos
    Canela, Enric, I
    Sanchez de Medina, Veronica
    del Ser-Badia, Anna
    Fuxe, Kjell
    Saura, Carlos A.
    Navarro, Gemma
    GLIA, 2019, 67 (12) : 2410 - 2423
  • [36] Adenosine A2A receptor antagonists are potential antidepressants:: evidence based on pharmacology and A2A receptor knockout mice
    El Yacoubi, M
    Ledent, C
    Parmentier, M
    Bertorelli, R
    Ongini, E
    Costentin, J
    Vaugeois, JM
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (01) : 68 - 77
  • [37] Potential of Adenosine A2A Receptor Antagonists in the Treatment of Movement Disorders
    Judit Mally
    Trevor W. Stone
    CNS Drugs, 1998, 10 : 311 - 320
  • [38] Identification of Novel Adenosine A2A Receptor Antagonists by Virtual Screening
    Langmead, Christopher J.
    Andrews, Stephen P.
    Congreve, Miles
    Errey, James C.
    Hurrell, Edward
    Marshall, Fiona H.
    Mason, Jonathan S.
    Richardson, Christine M.
    Robertson, Nathan
    Zhukov, Andrei
    Weir, Malcolm
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) : 1904 - 1909
  • [39] Metabolites of the Pyrimidine Amine Preladenant as Adenosine A2a Receptor Antagonists
    Rosse, Gerard
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (01): : 5 - 6
  • [40] Characterization of several adenosine A2A receptor antagonists using an in vivo pharmacological model of migraine
    Labastida-Ramirez, Alejandro
    Chan, Kayi Y.
    Haanes, Kristian A.
    de Vries, Rene
    Shook, Brian
    Jackson, Paul F.
    Zhang, Jimmy
    Flores, Christopher M.
    Villalon, Carlos M.
    MaassenVanDenBrink, Antoinette
    CEPHALALGIA, 2017, 37 : 75 - 76
12345