Enantiodivergent Synthesis of Cyclohexenyl Nucleosides

被引：14

作者：

Ferrer, Eric ^{[1
]}

Alibes, Ramon ^{[1
]}

Busque, Felix ^{[1
]}

Figueredo, Marta ^{[1
]}

Font, Josep ^{[1
]}

de March, Pedro ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 06期

关键词：

P-BENZOQUINONE; ANTIVIRAL ACTIVITY; ENANTIOSELECTIVE SYNTHESIS; POTENTIAL INHIBITORS; ASYMMETRIC-SYNTHESIS; VIRUS TYPE-1; MECHANISM; AGENT; RING;

D O I：

10.1021/jo802492g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiodivergent synthesis of several cyclohexenyl nucleosides has been efficiently completed starting from the enantiopure hydrobenzoin-derived monoketal of cyclohex-2-en-1,4-dione, (+)-5. Stereodiversity was accomplished on the base coupling step. This methodology has proved to be useful for the synthesis of enantiopure pyrimidine and purine nucleoside analogues, which anti-HIV activity has been evaluated.

引用

页码：2425 / 2432

页数：8

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