Expression of canine Kdap in normal, hyperplastic and neoplastic epidermis

被引：5

作者：

Yagihara, Hiroko ^{[1
]}

Kinjo, Emiko ^{[1
]}

Kobayashi, Yohei ^{[1
]}

Tsuji, Ayaka ^{[1
]}

Nishimura, Yudai ^{[1
]}

Shinozaki, Nao ^{[1
]}

Tamura, Kyoichi ^{[1
]}

Isotani, Mayu ^{[1
]}

Nakagaki, Kazuhide ^{[2
]}

Takahashi, Kimimasa ^{[3
]}

Ono, Kenichiro ^{[4
]}

Washizu, Tsukimi ^{[1
]}

Bonkobara, Makoto ^{[1
]}

机构：

[1] Nippon Vet & Life Sci Univ, Dept Vet Clin Pathol, Musashino, Tokyo 1808602, Japan

[2] Nippon Vet & Life Sci Univ, Lab Wildlife Med, Musashino, Tokyo 1808602, Japan

[3] Nippon Vet & Life Sci Univ, Div Vet Pathol, Musashino, Tokyo 1808602, Japan

[4] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Clin Pathobiol, Bunkyo Ku, Tokyo 1138657, Japan

来源：

VETERINARY JOURNAL | 2009年 / 180卷 / 03期

关键词：

Kdap; Epidermis; Hyperplasia; Squamous cell carcinoma; Canine; CYSTATIN M/E EXPRESSION; PROTEINASE-INHIBITOR; LAMELLAR GRANULES; GENE-EXPRESSION; DIFFERENTIATION; KERATINOCYTE; TRANSGLUTAMINASE; IDENTIFICATION; EPITHELIA; ENVELOPE;

D O I：

10.1016/j.tvjl.2008.01.006

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Keratinocyte differentiation-associated protein, Kdap, is a recently identified small secretory protein that may act as a Soluble regulator for the cornification and/or desquamation of keratinocytes. To clarify the role of Kdap in the terminal differentiation of keratinocytes, detailed in situ localisation of Kdap was studied using canine skin with normal, hyperplastic and neoplastic epidermis. In normal canine trunk skin, Kdap was expressed by granular keratinocytes, with polarity to the apical side of the cells, suggesting that canine Kdap is present in lamellar granules, as in humans. Expression of Kdap was widespread in the spinous layers in hyperplastic epidermis, but was undetectable in squamous cell carcinomas. These findings suggest that Kdap is closely related to the delay of terminal differentiation and/or release of cells in hyperplastic epidermis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：348 / 355

页数：8

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