Hypotensive properties and acute toxicity of trans-[Ru(NH3)4P(OEt)3(NO)](PF6)3, a new nitric oxide donor

被引：46
|
作者：
Torsoni, AS
de Barros, BF
Toledo, JC
Haun, M
Krieger, MH [1 ]
Tfouni, E
Franco, DW
机构：
[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Fisiol & Biofis, CP 6109, Campinas, SP, Brazil
[2] Univ Fed Sao Carlos, Inst Quim Sao Carlos, BR-13560 Sao Carlos, SP, Brazil
[3] Univ Fed Sao Carlos, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-13560 Sao Carlos, SP, Brazil
来源：
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2002年 / 6卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
nitric oxide donor; nitrovasodilator; blood pressure; metal-nitrosyl complexes; sodium nitroprusside; methylene blue; carboxy-PTIO;
D O I：
10.1006/niox.2001.0409
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hypotensive effect and the acute toxicity of trans-[Ru(NH3)(4)P(OEt)(3)(NO)](PF6)(3) (RuNO) were investigated in conscious animals. The approximate lethal dose of RuNO is 257.5 mumol/kg in mice i.p. and the IC50 values evaluated for V79 culture cell cytotoxicity were higher than 2.0 mM, suggesting that the ruthenium species are significantly less toxic than Na-2[Fe(CN)(5)(NO)] (SN-P) species. The RuNO hypotensive effect measured through in-bolus intravenous administration in chronically instrumented normotensive and hypotensive adult male Wistar rats is similar to that exhibited by equivalent doses of SNP. The hypotensive effect of the ruthenium complex is fully inhibited by methylene blue and PTIO, suggesting that the RuNO effect is likely to be primarily dependent on the NO-[cGMP] pathway in the smooth muscle cells. (C) 2002 Elsevier Science (USA).
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页码：247 / 254
页数：8
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