Copper (II)-Surfactant Complex and Its Nano Analog as Potential Antitumor Agents

被引：5
|
作者：
Badawi, Abdelftah M. [1 ]
Zakhary, Nadia I. [2 ]
Morsy, Salwa M. I. [1 ]
Sabry, Gilane M. [3 ]
Mohamed, Mohamed R. [3 ]
Mousa, Ahmed M. [1 ]
机构：
[1] Egyptian Petr Res Inst, Appl Surfactant Lab, Nasr City, Cairo, Egypt
[2] Cairo Univ, Natl Canc Inst, Cairo, Egypt
[3] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo, Egypt
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2009年 / 30卷 / 09期
关键词：
Antitumor agents; human cancer cell lines; in vitro anticancer activity; nano analog; surfactant complex; SELENIUM; CELLS; CHITOSAN;
D O I：
10.1080/01932690902735439
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The in vitro anticancer activity of copper cetyl trimethyl ammonium bromide (Cu-CTAB)-loaded cyclodextrin nanoparticles on Ehrlich ascites carcinoma (EAC), colon cancer cells (HCT 116), liver cancer cells (HepG-2), breast cancer cells (MCF-7), and cervix cancer cells (Hela) was investigated using MTT due assay. Cyclodextrin nanoparticles loaded with Cu-CTAB exerted in vitro anticancer activity against the previous human cancer cell lines comparable to the activity of free non-entrapped in nanoparticles macro-particle Cu-CTAB. The nano analog was synthesized by physical loading using grinding with ball mill. The ratio between Cu-CTAB and cyclodextrin oligosaccharide was 1 Cu-CTAB: 3 cyclodextrin. The particle size of the nano derivative was determined using the transmitted electron microscope (TEM).
引用
收藏
页码：1303 / 1309
页数：7
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