Proteomic signals in simple transcriptional cascades

被引:2
|
作者
Carstea, A. S. [1 ]
Ramani, A. [2 ]
Tamizhmani, K. M. [3 ]
Grammaticos, B. [4 ]
机构
[1] Inst Phys & Nucl Engn, Dept Theoret Phys, Bucharest 077125, Romania
[2] Ecole Polytech, CNRS, Ctr Phys Theor, F-91128 Palaiseau, France
[3] Pondicherry Univ, Dept Math, Kalapet 605014, Puducherry, India
[4] Univ Paris 11, IMNC, CNRS, UMR 8165, F-91406 Orsay, France
关键词
GENETIC TOGGLE SWITCH; ESCHERICHIA-COLI; EXPRESSION; BACTERIA; NETWORKS; MOTIFS; SYSTEM;
D O I
10.1016/j.chaos.2008.07.030
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
A transcriptional gene network cascade with activation or repression coupling is analysed. For different promoter activity functions and different degradation rate of transcription factors we show that a proteomic signal is propagating along the cascade in the form of a kink wave, It represents the time evolution of transcription factor distribution showing a successive gene expression along the cascade. Biological implications are discussed. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1823 / 1827
页数:5
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