Precision genome engineering through adenine and cytosine base editing

被引：59
|
作者：
Kim, Jin-Soo [1 ,2 ]
机构：
[1] Inst for Basic Sci Korea, Ctr Genome Engn, Seoul, South Korea
[2] Seoul Natl Univ, Dept Chem, Seoul, South Korea
来源：
NATURE PLANTS | 2018年 / 4卷 / 03期
关键词：
DNA; INVERSIONS; RICE;
D O I：
10.1038/s41477-018-0115-z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.
引用
收藏
页码：148 / 151
页数：4
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