Clinical Course of Children with Chronic Suppurative Lung Disease or Bronchiectasis Infected with Pseudomonas aeruginosa

被引:3
|
作者
Kartsiouni, Elpiniki [1 ]
Chatzipanagiotou, Stylianos [2 ]
Galani, Angeliki [1 ]
Moriki, Dafni [1 ]
Sardeli, Olympia [1 ]
Prountzos, Spyridon [3 ]
Alexopoulou, Efthymia [3 ]
Loukou, Ioanna [4 ]
Priftis, Kostas N. [1 ]
Douros, Konstantinos [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Pediat 3,Pediat Allergy & Resp Unit, Athens 12462, Greece
[2] Natl & Kapodistrian Univ Athens, Eginit Hosp, Sch Med, Dept Med Biopathol, Athens 11528, Greece
[3] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Radiol Dept 2, Athens 12462, Greece
[4] Agia Sofia Childrens Hosp, Cyst Fibrosis Dept, Athens 11527, Greece
来源
CHILDREN-BASEL | 2022年 / 9卷 / 12期
关键词
Pseudomonas aeruginosa; bronchiectasis; chronic suppurative lung disease; children; RESOLUTION CT-SCAN; CYSTIC-FIBROSIS;
D O I
10.3390/children9121822
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Children with chronic wet cough and without cystic fibrosis (non-CF) may suffer from chronic suppurative lung disease (CSLD) or bronchiectasis. Pseudomonas aeruginosa (Pa) can be one of the offending microbes in these children. The present study aimed to describe the clinical course of children with the above two conditions who were infected with Pa. Data of 54 children with CSLD/bronchiectasis who were diagnosed and attended in our department were retrospectively analysed through a Cox proportional hazard model, with age, presence of bronchiectasis, use of inhaled colistin, azithromycin, inhaled hypertonic saline as the covariates. In 42 of the 54 patients, there was no identifiable cause or underlying chronic disorder. Microbiological clearance was defined as the absence of daily wet cough for four months along with four negative cultures taken during the last four consecutive follow-up visits. Multivariate analysis was performed with a Cox proportional hazard model with time to microbiological clearance as the outcome. Results are described as Hazard Ratios (HR) with 95% Confidence Intervals (95%CI). Nebulised antibiotics and the presence of bronchiectasis were statistically significant predictors of remission (HR: 3.99; 95%CI: 1.12-14.14; p = 0.032, and HR: 0.24; 95%CI: 0.08-0.71; p = 0.010). In conclusion, the rate of microbiological clearance increases with the use of inhaled colistin and decreases when there is established bronchiectasis.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] ROLE OF PSEUDOMONAS-AERUGINOSA IN CHRONIC SUPPURATIVE OTITIS-MEDIA
    BROOK, I
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (04) : 355 - 356
  • [42] Outcome of surgery for chronic suppurative otitis media with resistant Pseudomonas aeruginosa
    O. Cavel
    O. J. Ungar
    Y. Oron
    R. Ben Ami
    M. Dekel
    O. Handzel
    European Archives of Oto-Rhino-Laryngology, 2021, 278 : 959 - 964
  • [44] Risk factors for Pseudomonas aeruginosa colonization bronchiectasis and clinical implications
    Jebali, R.
    Moussa, I.
    Sahnoun, I.
    Rejeb, S.
    Bougacha, M.
    El Gharbi, L. Douik
    El Gharbi, L. Douik
    EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [45] Clinical impact of major pathogenic genotypes of Pseudomonas aeruginosa associated with refractory chronic suppurative otitis media
    Lee, Chang Hyeon
    Kim, Kyu-Min
    Shin, Jeong-Ih
    Jeong, Da Min
    Byun, Jung-Hyun
    Jung, Myung Hwan
    Kang, Hyung-Lyun
    Kwon, Kee Woong
    Baik, Seung Chul
    Lee, Woo-Kon
    Ahn, Seong-Ki
    Yim, Chae Dong
    Hur, Dong Gu
    Lee, Jung Woo
    Shin, Min-Kyoung
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2024, 43 (12) : 2429 - 2440
  • [46] Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease
    Pizzutto, Susan J.
    Yerkovich, Stephanie T.
    Upham, John W.
    Hales, Belinda J.
    Thomas, Wayne R.
    Chang, Anne B.
    VACCINE, 2015, 33 (02) : 321 - 326
  • [47] The impact of COVID-19 on children with chronic suppurative lung disease
    Tolufase, Toulope
    Osinibi, Mira
    Kavaliunaite, Ema
    Thorogood, Mohammed
    Gupta, Atul
    Pierce, Sarah
    Bossley, Cara J.
    EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [48] Chronic suppurative lung disease in adults
    Metersky, Mark L.
    Mangardich, Antranik
    JOURNAL OF THORACIC DISEASE, 2016, 8 (09) : E974 - E978
  • [49] Effect of Inhaled Liposomal Ciprofloxacin on Severe Pulmonary Exacerbations in Patients with Bronchiectasis and Chronic Pseudomonas Aeruginosa Lung Infections
    Chalmers, J.
    Haworth, C.
    Davis, A. M.
    Gonda, I.
    Froehlich, J. K.
    O'Donnell, A. E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [50] Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media
    Rath, Sibanarayan
    Das, Saumya Ranjan
    Padhy, Rabindra Nath
    BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, 2017, 83 (02) : 201 - 206