Convenient synthesis and conversion of a (Z)-α,β-didehydroornithine derivative to α,β-didehydrokyotorphin

被引：0

作者：

Yonezawa, Y ^{[1
]}

Hirosaki, T ^{[1
]}

Hayashi, T ^{[1
]}

Shin, CG ^{[1
]}

机构：

[1] Kanagawa Univ, Fac Technol, Organ Chem Lab, Kanagawa Ku, Yokohama, Kanagawa 2218686, Japan

来源：

SYNTHESIS-STUTTGART | 2000年 / 01期

关键词：

amines; azides; peptides; condensations; coupling; reductions; didehydroamino acids; didehydroornithine;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrogenolysis of the azido group of methyl (Z)-2-(N-Cbz)amino-5-azidopent-2-enoate, derived by selective reduction and azidation of the side chain carboxyl group of N-protected (Z)-Delta Glu-OMe, gave (Z)-alpha,beta-didehydroornithine derivative (7). The formed 7 was further converted to the basic (Z)-alpha,beta-didehydroarginine and the acid containing (Z)-alpha, beta-didehydrokyotorphin.

引用

页码：144 / 148

页数：5

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