Immunohistochemical Mdm2 expression in minor salivary gland tumours and its relationship to p53 gene status

被引：5
|
作者：
de Araújo, VC
Martins, MT
Leite, KRM
Gomez, RS
de Araújo, NS
机构：
[1] Univ Sao Paulo, Fac Odontol, Disciplina Patol Oral, Sao Paulo, Brazil
[2] Sirio Libanes Hosp, Sao Paulo, Brazil
[3] Univ Fed Minas Gerais, Sch Dent, Dept Oral Pathol, Belo Horizonte, MG, Brazil
来源：
ORAL ONCOLOGY | 2000年 / 36卷 / 01期
关键词：
salivary gland tumours; p53; Mdm2;
D O I：
10.1016/S1368-8375(99)00054-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mdm2 protein is a cellular regulator of p53 protein activity. Minor salivary gland tumours were investigated for immunohistochemical expression of Mdm2 protein and for p53 gene status. Formalin-fixed sections were submitted to monoclonal antibody anti-Mdm2 through use of the streptavidin-biotin method. Nuclear immunoreactivity was scored 1 (0-25% nuclei positive), 2 (26-50%), 3 (51-75%) and 4 (> 75%). The scores found were: PLGA = 1-4; ACC = 3 and 4; ACA = 2 and 4; PA = 3. Genomic DNA of p53 gene exons 5-8 was examined by polymerase chain reaction and no alterations were detected. The strong immunohistochemical Mdm2 expression may represent an alternative mechanism to the development of salivary gland tumours. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：67 / 69
页数：3
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