p53 and MDM2 expression in odontogenic cysts and tumours

被引：0
|
作者：
Carvalhais, JN
de Aguiar, MCF
de Araújo, VC
de Araújo, NS
Gomez, RS
机构：
[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, BR-30380030 Belo Horizonte, MG, Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil
来源：
ORAL DISEASES | 1999年 / 5卷 / 03期
关键词：
p53; MDM2; odontogenic cysts; odontogenic tumours; immunohistochemistry;
D O I：
暂无
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis. MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours. RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear-cell odontogenic ametoblastoma presented strong immunoreaction to this antigen. CONCLUSIONS: The results suggest that MDM2 overexpression may be involved in the pathogenesis of some odontogenic lesions.
引用
收藏
页码：218 / 222
页数：5
相关论文
共 50 条
  • [1] Immunohistochemical expression of Mdm2 and p53 in canine cutaneous mast cell tumours
    Wu, H
    Hayashi, T
    Inoue, M
    [J]. JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 2006, 53 (02): : 65 - 68
  • [2] Immunohistochemical Comparison of the Expression of p53 and MDM2 Proteins in Ameloblastomas and Keratocystic Odontogenic Tumors
    Sharifi-Sistani, Noorieh
    Zartab, Hamed
    Babakoohi, Shahab
    Saghravanian, Nasrollah
    Jamshidi, Shokoofeh
    Esmaili, Habibollah
    Mohtasham, Nooshin
    Zamanzadeh, Maryam
    Abbaszadeh-Bidokhty, Hamid
    [J]. JOURNAL OF CRANIOFACIAL SURGERY, 2011, 22 (05) : 1652 - 1656
  • [3] MDM2 and p53 expression in ampullary adenocarcinomas
    Perysinakis, I.
    Leontara, V.
    Minaidou, E.
    Karambogias, C.
    Choreftaki, T.
    Zografos, G.
    Kouraklis, G.
    [J]. VIRCHOWS ARCHIV, 2015, 467 : S126 - S126
  • [4] PCNA and p53 expression odontogenic cysts
    Galvao, HC
    Souza, LB
    [J]. JOURNAL OF DENTAL RESEARCH, 2001, 80 (04) : 1097 - 1097
  • [5] p53 mutation and MDM2 amplification in inflammatory myofibroblastic tumours
    Yamamoto, H
    Oda, Y
    Saito, T
    Sakamoto, A
    Miyajima, K
    Tamiya, S
    Tsuneyoshi, M
    [J]. HISTOPATHOLOGY, 2003, 42 (05) : 431 - 439
  • [6] p53 protein expression in odontogenic cysts
    Piattelli, A
    Fioroni, M
    Santinelli, A
    Rubini, C
    [J]. JOURNAL OF ENDODONTICS, 2001, 27 (07) : 459 - 461
  • [7] Testicular germ cell tumours: p53/MDM2 expression and association with patient outcome
    Lobo, J.
    Alzamora, M. A.
    Guimaraes, R.
    Cantante, M.
    Lopes, P.
    Braga, I.
    Mauricio, J.
    Jeronimo, C.
    Henrique, R.
    [J]. VIRCHOWS ARCHIV, 2020, 477 : S162 - S162
  • [8] P53 Mdm2 Inhibitors
    Khoury, Kareem
    Doemling, Alex
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (30) : 4668 - 4678
  • [9] MDM2与p53
    金晶
    刘耕陶
    [J]. 癌症, 2001, (06) : 663 - 666
  • [10] MDM2 and BCL-2: to p53 or not to p53?
    Wang, Eunice S.
    [J]. BLOOD, 2023, 141 (11) : 1237 - 1238
12345