Composite lymphoma with relapse of enteropathy-type T-cell lymphoma

被引：5
|
作者：
Du, Zunguo [1 ]
Chen, Jieqing [2 ]
Zhou, Xiaoyan [3 ]
Zhang, Taiming [3 ]
Chen, Bobin [4 ]
Tang, Feng [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Pathol, Shanghai 200040, Peoples R China
[2] Univ Texas MD Anderson Canc Ctr, Dept Melanoma, Houston, TX 77030 USA
[3] Fudan Univ, Ctr Canc, Dept Mol Pathol, Shanghai 200040, Peoples R China
[4] Fudan Univ, Huashan Hosp, Dept Hematol, Shanghai 200040, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2009年 / 50卷 / 05期
关键词：
Composite lymphoma; diffuse large B-cell lymphoma; enteropathy-type T-cell lymphoma; duodenum; gene rearrangement; NON-HODGKINS-LYMPHOMA; CLINICAL-FEATURES; CLINICOPATHOLOGICAL ANALYSIS; TRANSPLANTATION; MULTICENTER; PRIMERS; CHOP;
D O I：
10.1080/10428190902795519
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We describe an unusual case of with de novo composite diffuse large B-cell lymphoma and enteropathy-type T-cell lymphoma involving the duodenum in a 65-year-old man with celiac disease. A segmental duodenum resection revealed that two neoplastic components had infiltrated the intestinal wall. The coexistence of two malignancies was confirmed by immunohistochemical and molecular biologic analysis, which revealed clonal T-cell receptor and immunoglobulin heavy chain gene rearrangements. Epstein-Barr virus was not detected in the B- and T-cell components. After chemotherapy, the patient experienced two relapses of enteropathy-type T-cell lymphoma only. We review the medical literature on composite B- and T-cell lymphomas and discuss their diagnosis, pathogenesis, prognosis and treatment.
引用
收藏
页码：749 / 756
页数：8
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